Literature DB >> 22851056

Prolonged remission from eltrombopag in chronic refractory idiopathic thrombocytopenic purpura.

V Noronha1, S D Philip, A Joshi, K Prabhash.   

Abstract

The therapy of ITP has recently been revolutionized with the introduction of thrombopoeitin stimulating agents. However, these medications are known to increase the platelet count only while the medication is being administered, with a rapid fall of the platelet count to baseline pre-therapy levels on discontinuation. We report the case of a patient with chronic refractory ITP who has attained a prolonged remission after a short course of eltrombopag, with normalization of the platelet count, which is sustained 8 months after discontinuation of the medication.

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Year:  2012        PMID: 22851056     DOI: 10.1007/s12185-012-1154-2

Source DB:  PubMed          Journal:  Int J Hematol        ISSN: 0925-5710            Impact factor:   2.490


  19 in total

Review 1.  Immune thrombocytopenic purpura.

Authors:  Douglas B Cines; Victor S Blanchette
Journal:  N Engl J Med       Date:  2002-03-28       Impact factor: 91.245

2.  Thrombopoietin signal transduction requires functional JAK2, not TYK2.

Authors:  J G Drachman; K M Millett; K Kaushansky
Journal:  J Biol Chem       Date:  1999-05-07       Impact factor: 5.157

3.  Population PK/PD modeling of eltrombopag in healthy volunteers and patients with immune thrombocytopenic purpura and optimization of response-guided dosing.

Authors:  Siobhan Hayes; Daniele Ouellet; Jianping Zhang; Mary B Wire; Ekaterina Gibiansky
Journal:  J Clin Pharmacol       Date:  2010-12-08       Impact factor: 3.126

Review 4.  How I treat idiopathic thrombocytopenic purpura (ITP).

Authors:  Douglas B Cines; James B Bussel
Journal:  Blood       Date:  2005-06-07       Impact factor: 22.113

Review 5.  Recombinant human thrombopoietin: basic biology and evaluation of clinical studies.

Authors:  David J Kuter; C Glenn Begley
Journal:  Blood       Date:  2002-11-15       Impact factor: 22.113

Review 6.  The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production.

Authors:  Kenneth Kaushansky; Jonathan G Drachman
Journal:  Oncogene       Date:  2002-05-13       Impact factor: 9.867

7.  Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro.

Authors:  Y Ezumi; H Takayama; M Okuma
Journal:  FEBS Lett       Date:  1995-10-23       Impact factor: 4.124

8.  Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura.

Authors:  James B Bussel; Gregory Cheng; Mansoor N Saleh; Bethan Psaila; Lidia Kovaleva; Balkis Meddeb; Janusz Kloczko; Habib Hassani; Bhabita Mayer; Nicole L Stone; Michael Arning; Drew Provan; Julian M Jenkins
Journal:  N Engl J Med       Date:  2007-11-29       Impact factor: 91.245

9.  Successful treatment with thrombopoietin receptor agonist in avoiding splenectomy for patients with chronic refractory immune thrombocytopenia.

Authors:  Alhossain Khalafallah; Zafreen Rahman; Kath Ogden; Terry Hannan
Journal:  Mediterr J Hematol Infect Dis       Date:  2012-01-18       Impact factor: 2.576

10.  Total remission of severe immune thrombocytopenia after short term treatment with romiplostim.

Authors:  Efthymia Vlachaki; Vaia Papageorgiou; Filippos Klonizakis; Maria Spandonidou; Sofia Chisan; Evaggelia Vetsiou; Elissavet Ioannidou
Journal:  Hematol Rep       Date:  2011-10-27
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  4 in total

1.  Reciprocal absence of cross-resistance between eltrombopag and romiplostim in two patients with refractory immune thrombocytopenic purpura.

Authors:  Laura Scaramucci; Marco Giovannini; Pasquale Niscola; Andrea Tendas; Alessio Perrotti; Paolo De Fabritiis
Journal:  Blood Transfus       Date:  2014-10       Impact factor: 3.443

Review 2.  Evidence-based management of immune thrombocytopenia: ASH guideline update.

Authors:  Cindy E Neunert; Nichola Cooper
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2018-11-30

3.  Efficacy and safety of eltrombopag in the treatment of severe chronic immune thrombocytopenia in children of China: A single-center observational study.

Authors:  Xiaoling Cheng; Kuo Yan; Jingyao Ma; Zhenping Chen; Libo Zhao; Xiaoling Wang; Runhui Wu
Journal:  Int J Immunopathol Pharmacol       Date:  2019 Jan-Dec       Impact factor: 3.219

4.  Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND/UCLA modified Delphi panel method.

Authors:  Adam Cuker; Jenny M Despotovic; Rachael F Grace; Caroline Kruse; Michele P Lambert; Howard A Liebman; Roger M Lyons; Keith R McCrae; Vinod Pullarkat; Jeffrey S Wasser; David Beenhouwer; Sarah N Gibbs; Irina Yermilov; Michael S Broder
Journal:  Res Pract Thromb Haemost       Date:  2020-12-08
  4 in total

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