Literature DB >> 22850524

Antibacterial activities of iron chelators against common nosocomial pathogens.

Mitchell G Thompson1, Brendan W Corey, Yuanzheng Si, David W Craft, Daniel V Zurawski.   

Abstract

The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

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Year:  2012        PMID： 22850524      PMCID： PMC3457357          DOI： 10.1128/AAC.01197-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

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Authors:  Russell E Lewis; Georgios N Pongas; Nathaniel Albert; Ronen Ben-Ami; Thomas J Walsh; Dimitrios P Kontoyiannis
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Review 3.  Iron chelation therapy and thalassemia - an overview.

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4.  Iron chelation via deferoxamine exacerbates experimental salmonellosis via inhibition of the nicotinamide adenine dinucleotide phosphate oxidase-dependent respiratory burst.

Authors:  Helen L Collins; Stefan H E Kaufmann; Ulrich E Schaible
Journal:  J Immunol       Date:  2002-04-01       Impact factor: 5.422

5.  A record of 1320 suspect, deferasirox-related, patient deaths reported in 2009: insufficient toxicity testing, low efficacy and lack of transparency may endanger the lives of iron loaded patients.

Authors:  George J Kontoghiorghes
Journal:  Hemoglobin       Date:  2011       Impact factor: 0.849

6.  Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats.

Authors:  Dorit Ben Shachar; Nava Kahana; Vladimir Kampel; Abraham Warshawsky; Moussa B H Youdim
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7.  Novel aroylhydrazone and thiosemicarbazone iron chelators with anti-malarial activity against chloroquine-resistant and -sensitive parasites.

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8.  Pulmonary invasive mucormycosis in a patient with secondary iron overload following deferoxamine therapy.

Authors:  Hector M Reyes; Eric J Tingle; Andrew Z Fenves; Jennifer Spiegel; Elizabeth C Burton
Journal:  Proc (Bayl Univ Med Cent)       Date:  2008-10

9.  Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium.

Authors:  Sofia Sousa Fernandes; Ana Nunes; Ana Rita Gomes; Baltazar de Castro; Robert C Hider; Maria Rangel; Rui Appelberg; Maria Salomé Gomes
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10.  Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients.

Authors:  Godfrey Chi-Fung Chan; Shing Chan; Pak-Leung Ho; Shau-Yin Ha
Journal:  Hemoglobin       Date:  2009       Impact factor: 0.849
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  48 in total

1.  Transposon Mutagenesis Screen of Klebsiella pneumoniae Identifies Multiple Genes Important for Resisting Antimicrobial Activities of Neutrophils in Mice.

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Review 2.  Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance.

Authors:  Savannah J Post; Justin A Shapiro; William M Wuest
Journal:  Medchemcomm       Date:  2019-03-21       Impact factor: 3.597

Review 3.  Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.

Authors:  Darren Wong; Travis B Nielsen; Robert A Bonomo; Paul Pantapalangkoor; Brian Luna; Brad Spellberg
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4.  The dual personality of iron chelators: growth inhibitors or promoters?

Authors:  Paolo Visca; Carlo Bonchi; Fabrizia Minandri; Emanuela Frangipani; Francesco Imperi
Journal:  Antimicrob Agents Chemother       Date:  2013-05       Impact factor: 5.191

5.  Reply to "The Dual personality of iron chelators: growth inhibitors or promoters?".

Authors:  Daniel V Zurawski; Anna C Jacobs; Mitchell G Thompson; Thomas J Palys
Journal:  Antimicrob Agents Chemother       Date:  2013-05       Impact factor: 5.191

6.  New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.

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Journal:  Antimicrob Agents Chemother       Date:  2014-05-12       Impact factor: 5.191

7.  Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris.

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Journal:  J Nat Prod       Date:  2017-08-25       Impact factor: 4.050

8.  Escherichia coli Free Radical-Based Killing Mechanism Driven by a Unique Combination of Iron Restriction and Certain Antibiotics.

Authors:  Li Ma; Yongjun Gao; Anthony W Maresso
Journal:  J Bacteriol       Date:  2015-09-21       Impact factor: 3.490

9.  Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis.

Authors:  Thiago M A Santos; Matthew G Lammers; Maoquan Zhou; Ian L Sparks; Madhusudan Rajendran; Dong Fang; Crystal L Y De Jesus; Gabriel F R Carneiro; Qiang Cui; Douglas B Weibel
Journal:  ACS Chem Biol       Date:  2017-12-20       Impact factor: 5.100

10.  In vitro and in vivo antimicrobial activities of gallium nitrate against multidrug-resistant Acinetobacter baumannii.

Authors:  Luísa C S Antunes; Francesco Imperi; Fabrizia Minandri; Paolo Visca
Journal:  Antimicrob Agents Chemother       Date:  2012-09-10       Impact factor: 5.191
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