Literature DB >> 22850520

In vitro activity of fluorescent dyes against asexual blood stages of Plasmodium falciparum.

Fanny Joanny1, Jana Held, Benjamin Mordmüller.   

Abstract

Many successful antimicrobial drugs originate from synthetic dyes. This paper reports the in vitro activity of 14 fluorescent dyes against Plasmodium falciparum. Five of these dyes (Hoechst 33342, MitoRed, DiOC(6), SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against two P. falciparum strains in the histidine-rich protein 2 drug sensitivity assay, while toxicity in HeLa cells is low. These dyes may be a starting point for developing new drugs against P. falciparum.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22850520      PMCID： PMC3486523          DOI： 10.1128/AAC.00709-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

Review 1.  Emerging drugs for malaria.

Authors:  Serena Tschan; Peter G Kremsner; Benjamin Mordmüller
Journal:  Expert Opin Emerg Drugs       Date:  2012-07-19       Impact factor: 4.191

2.  Reassessment of the resistance of Plasmodium falciparum to chloroquine in Gabon: implications for the validity of tests in vitro vs. in vivo.

Authors:  S Borrmann; R K Binder; A A Adegnika; M A Missinou; S Issifou; M Ramharter; W H Wernsdorfer; P G Kremsner
Journal:  Trans R Soc Trop Med Hyg       Date:  2002 Nov-Dec       Impact factor: 2.184

3.  Localization of mitochondria in living cells with rhodamine 123.

Authors:  L V Johnson; M L Walsh; L B Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

4.  Selective toxicity to malaria parasites by non-intercalating DNA-binding ligands.

Authors:  H Ginsburg; E Nissani; M Krugliak; D H Williamson
Journal:  Mol Biochem Parasitol       Date:  1993-03       Impact factor: 1.759

5.  Cytotoxicity, Mutagenicity and DNA damage by Hoechst 33342.

Authors:  R E Durand; P L Olive
Journal:  J Histochem Cytochem       Date:  1982-02       Impact factor: 2.479

6.  Inhibition of in vitro growth of Plasmodium falciparum by a brief exposure to the cationic rhodamine dyes.

Authors:  A Izumo; K Tanabe
Journal:  Ann Trop Med Parasitol       Date:  1986-06

7.  Effects of mitochondrial inhibitors on intraerythrocytic Plasmodium falciparum in in vitro cultures.

Authors:  H Ginsburg; A A Divo; T G Geary; M T Boland; J B Jensen
Journal:  J Protozool       Date:  1986-02

8.  A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures.

Authors:  A Y Chen; C Yu; A Bodley; L F Peng; L F Liu
Journal:  Cancer Res       Date:  1993-03-15       Impact factor: 12.701

9.  Acute exposure to rhodamine B.

Authors:  D J Dire; J A Wilkinson
Journal:  J Toxicol Clin Toxicol       Date:  1987

10.  Inhibitory effect of rhodamine 123 on the growth of the rodent malaria parasite, Plasmodium yoelii.

Authors:  K Tanabe
Journal:  J Protozool       Date:  1984-05
View more
  6 in total

1.  Effect of fluorescent dyes on in vitro-differentiated, late-stage Plasmodium falciparum gametocytes.

Authors:  Tamirat Gebru; Benjamin Mordmüller; Jana Held
Journal:  Antimicrob Agents Chemother       Date:  2014-09-29       Impact factor: 5.191

2.  Cell trace far-red is a suitable erythrocyte dye for multi-color Plasmodium falciparum invasion phenotyping assays.

Authors:  Laty G Thiam; Yaw Aniweh; Evelyn B Quansah; Jacob K Donkor; Theresa M Gwira; Kwadwo A Kusi; Makhtar Niang; Gordon A Awandare
Journal:  Exp Biol Med (Maywood)       Date:  2020-01-05

Review 3.  Acridine-Based Antimalarials-From the Very First Synthetic Antimalarial to Recent Developments.

Authors:  Mélanie Fonte; Natália Tassi; Paula Gomes; Cátia Teixeira
Journal:  Molecules       Date:  2021-01-24       Impact factor: 4.411

Review 4.  Recent advances in live cell imaging of hepatoma cells.

Authors:  Sandeep Salipalli; Prafull Kumar Singh; Jürgen Borlak
Journal:  BMC Cell Biol       Date:  2014-07-08       Impact factor: 4.241

5.  A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds.

Authors:  Leonardo Lucantoni; Francesco Silvestrini; Michele Signore; Giulia Siciliano; Maarten Eldering; Koen J Dechering; Vicky M Avery; Pietro Alano
Journal:  Sci Rep       Date:  2015-11-10       Impact factor: 4.379

Review 6.  Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria.

Authors:  María Álvarez-Bardón; Yolanda Pérez-Pertejo; César Ordóñez; Daniel Sepúlveda-Crespo; Nestor M Carballeira; Babu L Tekwani; Sankaranarayanan Murugesan; Maria Martinez-Valladares; Carlos García-Estrada; Rosa M Reguera; Rafael Balaña-Fouce
Journal:  Mar Drugs       Date:  2020-03-31       Impact factor: 5.118
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.