| Literature DB >> 22850474 |
Mahfoudh Abdulghani1, Abas Hj Hussin, Siti Amrah Sulaiman, Kit Lam Chan.
Abstract
The objective of this research was to study the ameliorative effects of a standardized quassinoid-rich extract (TAF 273) of Eurycoma longifolia root on some reproductive disorders in female rats. An irregular estrous cycle and ovarian cystic follicles were induced in 21-day-old females by the daily administration of testosterone (10 mg/kg, sc) for three weeks. The hormone-treated rats exhibited persistent diestrous as well as ovaries containing cystic follicles. Upon treatment with TAF 273, fewer animals showed irregular estrous cycles and there was less follicular morphological damage. The reversal effect may be derived from the anti-estrogenic properties of the plant quassinoids.Entities:
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Year: 2012 PMID： 22850474 DOI： 10.1016/s1642-431x(12)60089-8
Source DB: PubMed Journal: Reprod Biol ISSN： 1642-431X Impact factor: 2.376