| Literature DB >> 22850319 |
Norbert Vida1, Hana Svobodová, Lucie Rárová, Pavel Drašar, David Saman, Josef Cvačka, Zdeněk Wimmer.
Abstract
Three new polyamine conjugates with stigmasterol [(3β,22E)-stigmasta-5,22-dien-3-ol] were synthesized and subjected to basic antimicrobial and cytotoxic tests. The conjugate derived from spermine, (3β,22E)-stigmasta-5,22-dien-3-yl 4(12-amino-4,9-diaza-dodecylamino)-4-oxobutanoate (5c), displayed considerable antimicrobial activity on Staphylococcus aureus at low concentration (50 μg mL(-1)). The cytotoxic activity was tested on cells of human T-lymfoblastic leukemia (IC(50)=35.8 ± 10.3 μM (5c) and IC(50)=35.9 ± 5.7 μM (5b)) and normal human fibroblasts (IC(50)=38.0 ± 2.8 μM (5c) and IC(50)=45.5 ± 1.9 μM (5b)). Conjugate 5a displayed no activity in both tests.Entities:
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Year: 2012 PMID： 22850319 DOI： 10.1016/j.steroids.2012.07.009
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668