Literature DB >> 22850252

Bidirectional alloreactivity: A proposed microchimerism-based solution to the NIMA paradox.

William J Burlingham1, Gilles Benichou.   

Abstract

The NIMA paradox is the observation that in transplants of allogeneic kidneys or hematopoietic stem cells, siblings benefit from re-exposure to non-inherited maternal antigens (NIMA), whereas re-exposure to a transplant from mother herself, theoretically the ideal "NIMA" donor, does not yield clinical results superior to a father-donated allograft. Recent observations of bidirectional alloreactivity in kidney and cord blood transplantation offer a possible solution to this paradox. If correct, the proposed solution points the way to clinical applications of microchimerism in solid organ and hematopoetic transplants.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22850252      PMCID： PMC3442809          DOI： 10.4161/chim.21668

Source DB:  PubMed          Journal:  Chimerism        ISSN： 1938-1964


  64 in total

1.  Actively acquired tolerance of foreign cells.

Authors:  R E BILLINGHAM; L BRENT; P B MEDAWAR
Journal:  Nature       Date:  1953-10-03       Impact factor: 49.962

2.  Immunity to homologous grafted skin; the relationship between the antigens of blood and skin.

Authors:  P B MEDAWAR
Journal:  Br J Exp Pathol       Date:  1946-02

3.  Loss of tolerance to a maternal kidney transplant is selective for HLA class II: evidence from trans-vivo DTH and alloantibody analysis.

Authors:  W J Burlingham; E Jankowska-Gan; A VanBuskirk; C G Orosz; J H Lee; S Kusaka
Journal:  Hum Immunol       Date:  2000-12       Impact factor: 2.850

4.  Induced immune tolerance for kidney transplantation.

Authors:  John D Scandling; Stephan Busque; Judith A Shizuru; Edgar G Engleman; Samuel Strober
Journal:  N Engl J Med       Date:  2011-10-06       Impact factor: 91.245

5.  Reexposure of cord blood to noninherited maternal HLA antigens improves transplant outcome in hematological malignancies.

Authors:  Jon J van Rood; Cladd E Stevens; Jacqueline Smits; Carmelita Carrier; Carol Carpenter; Andromachi Scaradavou
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-09       Impact factor: 11.205

6.  Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies.

Authors:  Martina Wilke; Harry Dolstra; Frans Maas; Jos Pool; Rolf Brouwer; J H Frederik Falkenburg; Ashok Rebello; Femke Lamers; Ed Schuuring; Philip Kluin; Francis Brasseur; Els Goulmy
Journal:  Hematol J       Date:  2003

7.  HLA-mismatched renal transplantation without maintenance immunosuppression.

Authors:  Tatsuo Kawai; A Benedict Cosimi; Thomas R Spitzer; Nina Tolkoff-Rubin; Manikkam Suthanthiran; Susan L Saidman; Juanita Shaffer; Frederic I Preffer; Ruchuang Ding; Vijay Sharma; Jay A Fishman; Bimalangshu Dey; Dicken S C Ko; Martin Hertl; Nelson B Goes; Waichi Wong; Winfred W Williams; Robert B Colvin; Megan Sykes; David H Sachs
Journal:  N Engl J Med       Date:  2008-01-24       Impact factor: 91.245

8.  The role of donor-recipient relationship in long-term outcomes of living donor renal transplantation.

Authors:  Clifford D Miles; Douglas E Schaubel; Dandan Liu; Friedrich K Port; Panduranga S Rao
Journal:  Transplantation       Date:  2008-05-27       Impact factor: 4.939

Review 9.  Immigration control in the vertebrate body with special reference to chimerism.

Authors:  Anthony J S Davies
Journal:  Chimerism       Date:  2012 Jan-Mar

10.  Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection.

Authors:  G Benichou; P A Takizawa; C A Olson; M McMillan; E E Sercarz
Journal:  J Exp Med       Date:  1992-01-01       Impact factor: 14.307
View more
  7 in total

1.  Microchimerism and regulation in living related kidney transplant families.

Authors:  W John Haynes; Ewa Jankowska-Gan; Lynn Haynes; William J Burlingham
Journal:  Chimerism       Date:  2014

Review 2.  Hematopoietic stem cell infusion/transplantation for induction of allograft tolerance.

Authors:  Jose M M Granados; Gilles Benichou; Tatsuo Kawai
Journal:  Curr Opin Organ Transplant       Date:  2015-02       Impact factor: 2.640

Review 3.  Maintaining T cell tolerance of alloantigens: Lessons from animal studies.

Authors:  Kortney A Robinson; William Orent; Joren C Madsen; Gilles Benichou
Journal:  Am J Transplant       Date:  2018-08       Impact factor: 8.086

4.  Mother and child T cell receptor repertoires: deep profiling study.

Authors:  Ekaterina V Putintseva; Olga V Britanova; Dmitriy B Staroverov; Ekaterina M Merzlyak; Maria A Turchaninova; Mikhail Shugay; Dmitriy A Bolotin; Mikhail V Pogorelyy; Ilgar Z Mamedov; Vlasta Bobrynina; Mikhail Maschan; Yuri B Lebedev; Dmitriy M Chudakov
Journal:  Front Immunol       Date:  2013-12-25       Impact factor: 7.561

Review 5.  Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT).

Authors:  Andrea I Loewendorf; Marie Csete; Alan Flake
Journal:  Front Pharmacol       Date:  2015-01-06       Impact factor: 5.810

6.  Kinetics of Alloantigen-Specific Regulatory CD4 T Cell Development and Tissue Distribution After Donor-Specific Transfusion and Costimulatory Blockade.

Authors:  Yusuke Tomita; Miwa Satomi; William Bracamonte-Baran; Ewa Jankowska Gan; Andrea Szymczak Workman; Creg J Workman; Dario Angelo Alberto Vignali; William J Burlingham
Journal:  Transplant Direct       Date:  2016-04-21

7.  Patterns of Immune Regulation in Rhesus Macaque and Human Families.

Authors:  William J Burlingham; Ewa Jankowska-Gan; Steve Kempton; Lynn Haynes; Dixon B Kaufman
Journal:  Transplant Direct       Date:  2015-07-23
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.