BACKGROUND: The purpose of this study was to determine the feasibility of a randomized trial of resistance exercise in patients with head and neck cancer receiving radiation. METHODS:Fifteen patients with head and neck cancer receiving radiation were randomized to resistance exercise (using resistance bands) or control group. Resistance exercise occurred at the radiation therapy site (weeks 1-6) and home (weeks 7-12). RESULTS: No serious adverse events occurred related to resistance exercise. Medium to large effect size differences favoring resistance exercise versus control group were noted for perceived fatigue at 6 weeks (smaller increase in fatigue for resistance exercise group; 7.4 vs 15.4, effect size [d] = -0.64), quality of life at 6 weeks (-7.0 vs -14.4, d = 0.52), and chair rise time (seconds) at 6 and 12 weeks (-1.6 vs 0.4, d = -.63 and -1.9 vs 0.1, d = -0.60, respectively). CONCLUSIONS:Resistance exercise is safe and feasible in patients with head and neck cancer receiving radiation; a definitive trial is warranted.
RCT Entities:
BACKGROUND: The purpose of this study was to determine the feasibility of a randomized trial of resistance exercise in patients with head and neck cancer receiving radiation. METHODS: Fifteen patients with head and neck cancer receiving radiation were randomized to resistance exercise (using resistance bands) or control group. Resistance exercise occurred at the radiation therapy site (weeks 1-6) and home (weeks 7-12). RESULTS: No serious adverse events occurred related to resistance exercise. Medium to large effect size differences favoring resistance exercise versus control group were noted for perceived fatigue at 6 weeks (smaller increase in fatigue for resistance exercise group; 7.4 vs 15.4, effect size [d] = -0.64), quality of life at 6 weeks (-7.0 vs -14.4, d = 0.52), and chair rise time (seconds) at 6 and 12 weeks (-1.6 vs 0.4, d = -.63 and -1.9 vs 0.1, d = -0.60, respectively). CONCLUSIONS: Resistance exercise is safe and feasible in patients with head and neck cancer receiving radiation; a definitive trial is warranted.
Authors: Lauren C Capozzi; Kevin R Boldt; Harold Lau; Lisa Shirt; Barry Bultz; S Nicole Culos-Reed Journal: Support Care Cancer Date: 2014-09-27 Impact factor: 3.603
Authors: Colin Lavigne; Harold Lau; George Francis; S Nicole Culos-Reed; Guillaume Y Millet; Rosie Twomey Journal: Eur J Appl Physiol Date: 2020-04-06 Impact factor: 3.078
Authors: Shuang G Zhao; Neil B Alexander; Zora Djuric; Jessica Zhou; Yebin Tao; Matthew Schipper; Felix Y Feng; Avraham Eisbruch; Francis P Worden; Scott J Strath; Shruti Jolly Journal: Head Neck Date: 2015-10-07 Impact factor: 3.147
Authors: Sylvia L Crowder; Andrew D Frugé; Katherine G Douglas; Yi Tang Chen; Laura Moody; Ashley Delk-Licata; John W Erdman; Molly Black; William R Carroll; Sharon A Spencer; Julie L Locher; Wendy Demark-Wahnefried; Laura Q Rogers; Anna E Arthur Journal: J Acad Nutr Diet Date: 2019-01-17 Impact factor: 4.910