OBJECTIVE: To establish a normal range of birthweight with gestational age (GA) at delivery and examine the contribution of maternal characteristics in defining growth restriction in stillbirths. METHODS: In 69,895 normal singleton pregnancies, regression analysis was used to determine the association of birthweight with GA and maternal characteristics. The proportion of 290 stillbirths classified as small for GA depending on inclusion or exclusion of maternal characteristics was determined. RESULTS: In normal pregnancies, there was a polynomial association between birthweight and GA. Birthweight increased with maternal weight, height and parity and was lower in Africans and South Asians than in Caucasians. Birthweight for GA was reduced in antepartum stillbirths (n = 243; p < 0.0001) but not in intrapartum stillbirths (n = 47; p = 0.334). There was no significant difference in the proportion of antepartum stillbirths with birthweight below the 10th percentile when birthweight was corrected for GA only compared to correction for GA and maternal characteristics (53.1 vs. 54.3%). The birthweight was below the 10th percentile in 71.8% of antepartum stillbirths at <32 weeks' gestation, in 47.2% at 33-36 weeks and in 31.5% at ≥37 weeks. CONCLUSION: Correction of birthweight for maternal characteristics does not alter the proportion of stillbirths that are small for GA.
OBJECTIVE: To establish a normal range of birthweight with gestational age (GA) at delivery and examine the contribution of maternal characteristics in defining growth restriction in stillbirths. METHODS: In 69,895 normal singleton pregnancies, regression analysis was used to determine the association of birthweight with GA and maternal characteristics. The proportion of 290 stillbirths classified as small for GA depending on inclusion or exclusion of maternal characteristics was determined. RESULTS: In normal pregnancies, there was a polynomial association between birthweight and GA. Birthweight increased with maternal weight, height and parity and was lower in Africans and South Asians than in Caucasians. Birthweight for GA was reduced in antepartum stillbirths (n = 243; p < 0.0001) but not in intrapartum stillbirths (n = 47; p = 0.334). There was no significant difference in the proportion of antepartum stillbirths with birthweight below the 10th percentile when birthweight was corrected for GA only compared to correction for GA and maternal characteristics (53.1 vs. 54.3%). The birthweight was below the 10th percentile in 71.8% of antepartum stillbirths at <32 weeks' gestation, in 47.2% at 33-36 weeks and in 31.5% at ≥37 weeks. CONCLUSION: Correction of birthweight for maternal characteristics does not alter the proportion of stillbirths that are small for GA.
Authors: Jonathan B Carmichael; Hsiao-Pin Liu; David Janik; Terrence W Hallahan; Kypros H Nicolaides; David A Krantz Journal: Prenat Diagn Date: 2017-07-18 Impact factor: 3.050
Authors: Anna Kajdy; Jan Modzelewski; Aneta Cymbaluk-Płoska; Ewa Kwiatkowska; Magdalena Bednarek-Jędrzejek; Dariusz Borowski; Katarzyna Stefańska; Michał Rabijewski; Andrzej Torbé; Sebastian Kwiatkowski Journal: Int J Mol Sci Date: 2021-04-18 Impact factor: 5.923