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Literature DB >> 22846461

Expression and function of APP and its metabolites outside the central nervous system.

Abstract

Amyloid precursor protein (APP) derived amyloid beta (Aβ) peptides have been extensively investigated in Alzheimer's disease pathology of the brain. However, the function of full length APP in the central nervous system remains unclear. Even less is known about the function of this ubiquitously expressed protein and its metabolites outside of the central nervous system. This review summarizes key aspects of the current understanding of the expression and function of APP and its proteolytic fragments in specific non-neuronal tissues.

Entities: CellLine Chemical Disease Gene Species

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Year: 2012 PMID： 22846461 PMCID： PMC3505247 DOI： 10.1016/j.exger.2012.07.009

Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032

30 in total

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Authors: Kendra L Puig; Adam J Swigost; Xudong Zhou; Mary Ann Sens; Colin K Combs
Journal: J Neuroimmune Pharmacol Date: 2011-11-29 Impact factor: 4.147

2. beta-amyloid or its precursor protein is found in epithelial cells of the small intestine and is stimulated by high-fat feeding.

Authors: Susan Galloway; Le Jian; Russell Johnsen; Stewart Chew; John C L Mamo
Journal: J Nutr Biochem Date: 2006-09-07 Impact factor: 6.048

Review 3. Inclusion-body myositis: a myodegenerative conformational disorder associated with Abeta, protein misfolding, and proteasome inhibition.

Authors: Valerie Askanas; W King Engel
Journal: Neurology Date: 2006-01-24 Impact factor: 9.910

4. A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation.

Authors: J Hoffmann; C Twiesselmann; M P Kummer; P Romagnoli; V Herzog
Journal: Eur J Cell Biol Date: 2000-12 Impact factor: 4.492

5. Tissue-specific expression of three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer's disease brain.

Authors: S Tanaka; S Shiojiri; Y Takahashi; N Kitaguchi; H Ito; M Kameyama; J Kimura; S Nakamura; K Ueda
Journal: Biochem Biophys Res Commun Date: 1989-12-29 Impact factor: 3.575

6. Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes.

Authors: Grit Sommer; Susan Kralisch; Jana Lipfert; Sebastian Weise; Kerstin Krause; Beate Jessnitzer; Ulrike Lössner; Matthias Blüher; Michael Stumvoll; Mathias Fasshauer
Journal: J Cell Biochem Date: 2009-12-15 Impact factor: 4.429

7. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.

Authors: Jasmina B Mackic; James Bading; Jorge Ghiso; Larry Walker; Thomas Wisniewski; Blas Frangione; Berislav V Zlokovic
Journal: Vascul Pharmacol Date: 2002-06 Impact factor: 5.773

8. Biology and pathophysiology of the amyloid precursor protein.

Authors: Hui Zheng; Edward H Koo
Journal: Mol Neurodegener Date: 2011-04-28 Impact factor: 14.195

9. Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity.

Authors: Kendra L Puig; Angela M Floden; Ramchandra Adhikari; Mikhail Y Golovko; Colin K Combs
Journal: PLoS One Date: 2012-01-19 Impact factor: 3.240

10. Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon.

Authors: Malgorzata Romanowska; Alan Evans; David Kellock; Susan E Bray; Kathleen McLean; Susanne Donandt; John Foerster
Journal: PLoS One Date: 2009-04-28 Impact factor: 3.240

21 in total

1. Amyloid precursor protein in pancreatic islets.

Authors: Joshua A Kulas; Kendra L Puig; Colin K Combs
Journal: J Endocrinol Date: 2017-07-14 Impact factor: 4.286

2. Overexpression of mutant amyloid-β protein precursor and presenilin 1 modulates enteric nervous system.

Authors: Kendra L Puig; Brianna M Lutz; Siri A Urquhart; Andrew A Rebel; Xudong Zhou; Gunjan D Manocha; MaryAnn Sens; Ashok K Tuteja; Norman L Foster; Colin K Combs
Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472

3. Unraveling the genes implicated in Alzheimer's disease.

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Journal: Biomed Rep Date: 2017-06-14

4. Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice.

Authors: Gunjan D Manocha; Angela M Floden; Nicole M Miller; Abbie J Smith; Kumi Nagamoto-Combs; Takashi Saito; Takaomi C Saido; Colin K Combs
Journal: Neurobiol Aging Date: 2019-06-13 Impact factor: 4.673

5. Salivary Aβ Secretion and Altered Oral Microbiome in Mouse Models of AD.

Authors: Angela M Floden; Mona Sohrabi; Suba Nookala; Jay J Cao; Colin K Combs
Journal: Curr Alzheimer Res Date: 2020 Impact factor: 3.498

Review 6. Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules.

Authors: Samantha L Hodges; Alexandra A Bouza; Lori L Isom
Journal: Pharmacol Rev Date: 2022-10 Impact factor: 18.923