Pilot testing of an HIV medication adherence intervention in a public clinic in the Deep South.

PURPOSE: Strict adherence to HIV medications is critical to ensure long-term disease control, and adherence interventions that are possible in a clinic setting with limited resources are needed. DATA SOURCES: This randomized controlled pilot study tested an adherence intervention guided by the Information-Motivation-Behavioral Skills (IMB) model. The intervention included HIV education, a peer video, motivational interviewing, and attention to behavioral skills including communication with providers and adherence-enhancing devices. Dependent variables included 3-4 week adherence recall, medication refill rate, changes in IMB subscale scores, appointment attendance, and HIV-associated laboratory findings. Seventy-three individuals starting or restarting antiretroviral therapy were enrolled and 56 were randomized.
CONCLUSIONS: Improvements were seen in most outcomes, with small to moderate effect sizes, but the study was not powered to show statistical significance. Threats to power included a 51% attrition rate, resulting mostly from loss to clinical care or prolonged gaps in care. IMPLICATIONS FOR PRACTICE: A telephone-based intervention to improve HIV medication adherence shows promise. Further study is needed with greater attention to retention in care. ©2012 The Author(s) Journal compilation ©2012 American Academy of Nurse Practitioners.

RCT Entities:   Population Interventions Outcomes