OBJECTIVE: To examine the risk of lung cancer among men associated with exposure to diesel engine emissions incurred in a wide range of occupations and industries. METHODOLOGY: 2 population-based lung cancer case-control studies were conducted in Montreal. Study I (1979-1986) comprised 857 cases and 533 population controls; study II (1996-2001) comprised 736 cases and 894 population controls. A detailed job history was obtained, from which we inferred lifetime occupational exposure to 294 agents, including diesel engine emissions. ORs were estimated for each study and in the pooled data set, adjusting for socio-demographic factors, smoking history and selected occupational carcinogens. While it proved impossible to retrospectively estimate absolute exposure concentrations, there were estimates and analyses by relative measures of cumulative exposure. RESULTS: Increased risks of lung cancer were found in both studies. The pooled analysis showed an OR of lung cancer associated with substantial exposure to diesel exhaust of 1.80 (95% CI 1.3 to 2.6). The risk associated with substantial exposure was higher for squamous cell carcinomas (OR 2.09; 95% CI 1.3 to 3.2) than other histological types. Joint effects between diesel exhaust exposure and tobacco smoking are compatible with a multiplicative synergistic effect. DISCUSSION: Our findings provide further evidence supporting a causal link between diesel engine emissions and risk of lung cancer. The risk is stronger for the development of squamous cell carcinomas than for small cell tumours or adenocarcinomas.
OBJECTIVE: To examine the risk of lung cancer among men associated with exposure to diesel engine emissions incurred in a wide range of occupations and industries. METHODOLOGY: 2 population-based lung cancer case-control studies were conducted in Montreal. Study I (1979-1986) comprised 857 cases and 533 population controls; study II (1996-2001) comprised 736 cases and 894 population controls. A detailed job history was obtained, from which we inferred lifetime occupational exposure to 294 agents, including diesel engine emissions. ORs were estimated for each study and in the pooled data set, adjusting for socio-demographic factors, smoking history and selected occupational carcinogens. While it proved impossible to retrospectively estimate absolute exposure concentrations, there were estimates and analyses by relative measures of cumulative exposure. RESULTS: Increased risks of lung cancer were found in both studies. The pooled analysis showed an OR of lung cancer associated with substantial exposure to diesel exhaust of 1.80 (95% CI 1.3 to 2.6). The risk associated with substantial exposure was higher for squamous cell carcinomas (OR 2.09; 95% CI 1.3 to 3.2) than other histological types. Joint effects between diesel exhaust exposure and tobacco smoking are compatible with a multiplicative synergistic effect. DISCUSSION: Our findings provide further evidence supporting a causal link between diesel engine emissions and risk of lung cancer. The risk is stronger for the development of squamous cell carcinomas than for small cell tumours or adenocarcinomas.
Authors: Jean-François Sauvé; Jack Siemiatycki; France Labrèche; Lesley Richardson; Javier Pintos; Marie-Pierre Sylvestre; Michel Gérin; Denis Bégin; Aude Lacourt; Tracy L Kirkham; Thomas Rémen; Romain Pasquet; Mark S Goldberg; Marie-Claude Rousseau; Marie-Élise Parent; Jérôme Lavoué Journal: Ann Work Expo Health Date: 2018-08-13 Impact factor: 2.179
Authors: Calvin Ge; Susan Peters; Ann Olsson; Lützen Portengen; Joachim Schüz; Josué Almansa; Wolfgang Ahrens; Vladimir Bencko; Simone Benhamou; Paolo Boffetta; Bas Bueno-de-Mesquita; Neil Caporaso; Dario Consonni; Paul Demers; Eleonóra Fabiánová; Guillermo Fernández-Tardón; John Field; Francesco Forastiere; Lenka Foretova; Pascal Guénel; Per Gustavsson; Vladimir Janout; Karl-Heinz Jöckel; Stefan Karrasch; Maria Teresa Landi; Jolanta Lissowska; Danièle Luce; Dana Mates; John McLaughlin; Franco Merletti; Dario Mirabelli; Tamás Pándics; Marie-Élise Parent; Nils Plato; Hermann Pohlabeln; Lorenzo Richiardi; Jack Siemiatycki; Beata Świątkowska; Adonina Tardón; Heinz-Erich Wichmann; David Zaridze; Kurt Straif; Hans Kromhout; Roel Vermeulen Journal: Am J Respir Crit Care Med Date: 2020-08-01 Impact factor: 21.405
Authors: Aude Lacourt; Javier Pintos; Jérôme Lavoué; Lesley Richardson; Jack Siemiatycki Journal: BMC Public Health Date: 2015-09-22 Impact factor: 3.295
Authors: Séverine Tual; Debra T Silverman; Stella Koutros; Aaron Blair; Dale P Sandler; Pierre Lebailly; Gabriella Andreotti; Jane A Hoppin; Laura E Beane Freeman Journal: Environ Health Perspect Date: 2015-10-09 Impact factor: 9.031