OBJECTIVE: To systematically study abnormalities in cytokine profiles in polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome, which has been increasingly recognized as a cause of demyelinating neuropathy associated with plasma cell dyscrasia and elevated serum level of vascular endothelial growth factor (VEGF). METHODS: In this case-control study, we measured serum levels of 27 cytokines in patients with POEMS syndrome using a multiplex suspension array system, and compared them with those of controls. In 10 patients, serial changes after treatment were analyzed. RESULTS: Interleukin (IL)-12 as well as VEGF levels were markedly increased (p < 0.0001) in all the patients (n = 23). Ten kinds of other proinflammatory cytokines such as IL-6 and tumor necrosis factor-α were also significantly increased in the POEMS syndrome group, but in some patients the serum levels of such cytokines remained within the normal ranges. After treatments, the IL-12 as well as VEGF levels significantly decreased with clinical improvements (p > 0.01 and p > 0.05, respectively). CONCLUSIONS: Our findings suggest that serum IL-12 is a biomarker of the disease activity in POEMS syndrome. The overproduction of IL-12, as well as VEGF, is likely to play an important role in the pathogenesis of the disorder, and could contribute to the peripheral nerve demyelination in POEMS syndrome.
OBJECTIVE: To systematically study abnormalities in cytokine profiles in polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome, which has been increasingly recognized as a cause of demyelinating neuropathy associated with plasma cell dyscrasia and elevated serum level of vascular endothelial growth factor (VEGF). METHODS: In this case-control study, we measured serum levels of 27 cytokines in patients with POEMS syndrome using a multiplex suspension array system, and compared them with those of controls. In 10 patients, serial changes after treatment were analyzed. RESULTS: Interleukin (IL)-12 as well as VEGF levels were markedly increased (p < 0.0001) in all the patients (n = 23). Ten kinds of other proinflammatory cytokines such as IL-6 and tumor necrosis factor-α were also significantly increased in the POEMS syndrome group, but in some patients the serum levels of such cytokines remained within the normal ranges. After treatments, the IL-12 as well as VEGF levels significantly decreased with clinical improvements (p > 0.01 and p > 0.05, respectively). CONCLUSIONS: Our findings suggest that serum IL-12 is a biomarker of the disease activity in POEMS syndrome. The overproduction of IL-12, as well as VEGF, is likely to play an important role in the pathogenesis of the disorder, and could contribute to the peripheral nerve demyelination in POEMS syndrome.
Authors: Gordon Cook; Simona Iacobelli; Anja van Biezen; Dimitris Ziagkos; Veronique LeBlond; Julie Abraham; Grant McQuaker; Stefan Schoenland; Alessandro Rambaldi; Kazimierz Halaburda; Maria Rovira; Simona Sica; Jenny Byrne; Ramon Garcia Sanz; Arnon Nagler; Niels W C J van de Donk; Marjatta Sinisalo; Mark Cook; Nicolaus Kröger; Theo De Witte; Curly Morris; Laurant Garderet Journal: Haematologica Date: 2016-09-15 Impact factor: 9.941
Authors: Ezequiel A Piccione; Janean Engelstad; Peter J Dyck; Michelle L Mauermann; Angela Dispenzieri; P James B Dyck Journal: Acta Neuropathol Commun Date: 2016-10-31 Impact factor: 7.801
Authors: S Misawa; Y Sato; K Katayama; H Hanaoka; S Sawai; M Beppu; F Nomura; K Shibuya; Y Sekiguchi; Y Iwai; K Watanabe; H Amino; C Ohwada; M Takeuchi; E Sakaida; C Nakaseko; S Kuwabara Journal: BMJ Open Date: 2015-11-11 Impact factor: 2.692