Arif Kokcu1, Erhan Yavuz, Handan Celik, Devran Bildircin. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis, Kurupelit, 55139 Samsun, Turkey. arifkokcu@yahoo.com
Abstract
PURPOSE: To examine the possible roles of various immunological factors in recurrent miscarriage and unexplained infertility. METHODS: The synthesis and review of the relevant current literature in English language. RESULTS: Substantial evidence suggests that antiphospholipid antibodies, lupus anticoagulant, antisperm antibodies, antithyroid antibodies, anti-endometrial antibodies, antiovarian antibodies, anti-C trachomatis antibodies, cytokines, and immunological events in endometriosis and premature ovarian failure due to immunologic factors may contribute to reproductive failure including unexplained infertility and/or non-chromosomal recurrent miscarriage. CONCLUSIONS: Elimination or suppression of the immunological factors related with reproductive failure might occupy an important place in the treatment of unexplained infertility and non-chromosomal recurrent miscarriage.
PURPOSE: To examine the possible roles of various immunological factors in recurrent miscarriage and unexplained infertility. METHODS: The synthesis and review of the relevant current literature in English language. RESULTS: Substantial evidence suggests that antiphospholipid antibodies, lupus anticoagulant, antisperm antibodies, antithyroid antibodies, anti-endometrial antibodies, antiovarian antibodies, anti-C trachomatis antibodies, cytokines, and immunological events in endometriosis and premature ovarian failure due to immunologic factors may contribute to reproductive failure including unexplained infertility and/or non-chromosomal recurrent miscarriage. CONCLUSIONS: Elimination or suppression of the immunological factors related with reproductive failure might occupy an important place in the treatment of unexplained infertility and non-chromosomal recurrent miscarriage.