| Literature DB >> 22842455 |
Tomohiro Yamauchi1, Naoto Nakamura, Masashi Hiramoto, Masatoshi Yuri, Hiroyuki Yokota, Masanori Naitou, Masahiro Takeuchi, Kentaro Yamanaka, Aya Kita, Takahito Nakahara, Isao Kinoyama, Akira Matsuhisa, Naoki Kaneko, Hiroshi Koutoku, Masao Sasamata, Masato Kobori, Masao Katou, Shuichi Tawara, Shigeki Kawabata, Kiyoshi Furuichi.
Abstract
YM155, a small-molecule survivin suppressant, specifically binds to the transcription factor ILF3, which regulates the expression of survivin[1]. In this experiment we have demonstrated that p54(nrb) binds to the survivin promoter and regulates survivin expression. p54(nrb) forms a complex with ILF3, which directly binds to YM155. YM155 induces disruption of the ILF3/p54(nrb) complex, which results in a different subcellular localization between ILF3 and p54(nrb). Thus, identification of molecular targets of YM155 in suppression of the survivin pathway, might lead to development of its use as a novel potential target in cancers.Entities:
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Year: 2012 PMID： 22842455 DOI： 10.1016/j.bbrc.2012.07.103
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.322