Liu Hong1, Jianjun Yang, Yu Han, Qun Lu, Jun Cao, Labiq Syed. 1. Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. hongliu180@126.com
Abstract
BACKGROUND: Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival. METHODS: A meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated. RESULTS: A total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% CI: 2.04-5.63, P<0.05), which could significantly predict poorer survival. CONCLUSIONS: High expression of miR-210 might predict poor survival in patients with breast cancer.
BACKGROUND: Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in humanbreast cancer and analyze the predicting role of miR-210 for survival. METHODS: A meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated. RESULTS: A total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% CI: 2.04-5.63, P<0.05), which could significantly predict poorer survival. CONCLUSIONS: High expression of miR-210 might predict poor survival in patients with breast cancer.
Authors: Daohong Chen; Chirayu P Goswami; Riesa M Burnett; Manjushree Anjanappa; Poornima Bhat-Nakshatri; William Muller; Harikrishna Nakshatri Journal: Cancer Res Date: 2014-06-30 Impact factor: 12.701