Literature DB >> 22841599

Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase.

Baoquan Che1, Lin Wang, Zhe Zhang, Yongqian Zhang, Yulin Deng.   

Abstract

Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22841599     DOI： 10.1016/j.neuro.2012.07.004

Source DB:  PubMed          Journal:  Neurotoxicology        ISSN： 0161-813X            Impact factor:   4.294


  7 in total

1.  Autopsy report for a caffeine intoxication case and review of the current literature.

Authors:  Takuma Yamamoto; Katsuhiko Yoshizawa; Shin-Ichi Kubo; Yuko Emoto; Kenji Hara; Brian Waters; Takahiro Umehara; Takehiko Murase; Kazuya Ikematsu
Journal:  J Toxicol Pathol       Date:  2014-12-07       Impact factor: 1.628

2.  Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.

Authors:  Motoki Fujimaki; Shinji Saiki; Yuanzhe Li; Naoko Kaga; Hikari Taka; Taku Hatano; Kei-Ichi Ishikawa; Yutaka Oji; Akio Mori; Ayami Okuzumi; Takahiro Koinuma; Shin-Ichi Ueno; Yoko Imamichi; Takashi Ueno; Yoshiki Miura; Manabu Funayama; Nobutaka Hattori
Journal:  Neurology       Date:  2018-01-03       Impact factor: 9.910

Review 3.  Beneficial Impact of Semicarbazide-Sensitive Amine Oxidase Inhibition on the Potential Cytotoxicity of Creatine Supplementation in Type 2 Diabetes Mellitus.

Authors:  Dimitri Papukashvili; Nino Rcheulishvili; Yulin Deng
Journal:  Molecules       Date:  2020-04-27       Impact factor: 4.411

Review 4.  Caffeine: An Overview of Its Beneficial Effects in Experimental Models and Clinical Trials of Parkinson's Disease.

Authors:  Giovanni Schepici; Serena Silvestro; Placido Bramanti; Emanuela Mazzon
Journal:  Int J Mol Sci       Date:  2020-07-04       Impact factor: 5.923

5.  Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue.

Authors:  Wiem Haj Ahmed; Cécile Peiro; Jessica Fontaine; Barry J Ryan; Gemma K Kinsella; Jeff O'Sullivan; Jean-Louis Grolleau; Gary T M Henehan; Christian Carpéné
Journal:  Medicines (Basel)       Date:  2020-04-02

Review 6.  Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO.

Authors:  Dimitri Papukashvili; Nino Rcheulishvili; Yulin Deng
Journal:  Nutrients       Date:  2020-01-09       Impact factor: 5.717

7.  Shared Metabolic Profile of Caffeine in Parkinsonian Disorders.

Authors:  Haruka Takeshige-Amano; Shinji Saiki; Motoki Fujimaki; Shin-Ichi Ueno; Yuanzhe Li; Taku Hatano; Kei-Ichi Ishikawa; Yutaka Oji; Akio Mori; Ayami Okuzumi; Taiji Tsunemi; Kensuke Daida; Yuta Ishiguro; Yoko Imamichi; Hisayoshi Nanmo; Shuko Nojiri; Manabu Funayama; Nobutaka Hattori
Journal:  Mov Disord       Date:  2020-05-01       Impact factor: 10.338
  7 in total

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