Literature DB >> 22841304

Have you heard? Viral-mediated gene therapy restores hearing.

Donna M Martin1, Yehoash Raphael.   

Abstract

Genetic loss of VGLUT3 in cochlear inner hair cells results in profound deafness. In this issue of Neuron, Akil et al. (2012) show that AAV-mediated introduction of wild-type VGLUT3 in the genetically deaf mouse cochlea results in significantly improved hearing.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22841304      PMCID： PMC4502432          DOI： 10.1016/j.neuron.2012.06.008

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  9 in total

Review 1.  Deafness in the genomics era.

Authors:  A Eliot Shearer; Michael S Hildebrand; Christina M Sloan; Richard J H Smith
Journal:  Hear Res       Date:  2011-10-08       Impact factor: 3.208

2.  Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene.

Authors:  F J Probst; R A Fridell; Y Raphael; T L Saunders; A Wang; Y Liang; R J Morell; J W Touchman; R H Lyons; K Noben-Trauth; T B Friedman; S A Camper
Journal:  Science       Date:  1998-05-29       Impact factor: 47.728

Review 3.  Hereditary hearing loss: from human mutation to mechanism.

Authors:  Danielle R Lenz; Karen B Avraham
Journal:  Hear Res       Date:  2011-06-06       Impact factor: 3.208

4.  In vitro and in vivo suppression of GJB2 expression by RNA interference.

Authors:  Yukihide Maeda; Kunihiro Fukushima; Kazunori Nishizaki; Richard J H Smith
Journal:  Hum Mol Genet       Date:  2005-04-27       Impact factor: 6.150

5.  Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.

Authors:  Jérôme Ruel; Sarah Emery; Régis Nouvian; Tiphaine Bersot; Bénédicte Amilhon; Jana M Van Rybroek; Guy Rebillard; Marc Lenoir; Michel Eybalin; Benjamin Delprat; Theru A Sivakumaran; Bruno Giros; Salah El Mestikawy; Tobias Moser; Richard J H Smith; Marci M Lesperance; Jean-Luc Puel
Journal:  Am J Hum Genet       Date:  2008-08       Impact factor: 11.025

Review 6.  Deafness genes and their diagnostic applications.

Authors:  Kim Cryns; Guy Van Camp
Journal:  Audiol Neurootol       Date:  2004 Jan-Feb       Impact factor: 1.854

7.  Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.

Authors:  Rebecca P Seal; Omar Akil; Eunyoung Yi; Christopher M Weber; Lisa Grant; Jong Yoo; Amanda Clause; Karl Kandler; Jeffrey L Noebels; Elisabeth Glowatzki; Lawrence R Lustig; Robert H Edwards
Journal:  Neuron       Date:  2008-01-24       Impact factor: 17.173

8.  Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma.

Authors:  G Richard; T W White; L E Smith; R A Bailey; J G Compton; D L Paul; S J Bale
Journal:  Hum Genet       Date:  1998-10       Impact factor: 4.132

9.  Molecular cloning and functional characterization of human vesicular glutamate transporter 3.

Authors:  Shigeo Takamori; Pari Malherbe; Clemens Broger; Reinhard Jahn
Journal:  EMBO Rep       Date:  2002-07-15       Impact factor: 8.807
  9 in total
  1 in total

Review 1.  Sound strategies for hearing restoration.

Authors:  Gwenaëlle S G Géléoc; Jeffrey R Holt
Journal:  Science       Date:  2014-05-09       Impact factor: 47.728
  1 in total

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