Literature DB >> 228395

Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation.

J Larner, G Galasko, K Cheng, A A DePaoli-Roach, L Huang, P Daggy, J Kellogg.   

Abstract

Deproteinized skeletal muscle extracts free of major nucleotides from control and insulin-treated rats were fractionated and assayed for inhibition of protein phosphorylation by cyclic adenosine monophosphate (AMP)-dependent and -independent protein kinases. A differential effect of insulin on a particular fraction was observed on cyclic AMP-dependent protein kinase but not on cyclic AMP-independent protein kinases. This fraction that inhibited cyclic AMP-dependent protein kinase also stimulated glycogen synthase phosphoprotein phosphatase. It is proposed that this fraction may contain a mediator substance generateed in the presence of insulin.

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Year:  1979        PMID： 228395     DOI： 10.1126/science.228395

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  53 in total

Review 1.  Mechanisms of receptor-mediated transmembrane signalling.

Authors:  M D Hollenberg
Journal:  Experientia       Date:  1986-07-15

Review 2.  Insulin receptors and the clinician.

Authors:  R Taylor
Journal:  Br Med J (Clin Res Ed)       Date:  1986-04-05

3.  Activation of phosphoprotein phosphatases by growth hormone sequences with insulin-like activity.

Authors:  S L Macaulay; J D Newman; J M Armstrong; J Bornstein
Journal:  Mol Cell Biochem       Date:  1987-03       Impact factor: 3.396

4.  Effects of glucagon and insulin on the cyclic AMP binding capacity of hepatocyte cyclic AMP-dependent protein kinase.

Authors:  C J Ciudad; J Vila; M A Mor; J J Guinovart
Journal:  Mol Cell Biochem       Date:  1987-01       Impact factor: 3.396

5.  Receptor-mediated insulin degradation and insulin-stimulated glycogenesis in cultured foetal hepatocytes.

Authors:  C Plas; B Desbuquois
Journal:  Biochem J       Date:  1982-02-15       Impact factor: 3.857

6.  The endogenous cyclic AMP antagonist, cyclic PIP: its ubiquity, hormone-stimulated synthesis and identification as prostaglandylinositol cyclic phosphate.

Authors:  H K Wasner; U Salge; M Gebel
Journal:  Acta Diabetol       Date:  1993       Impact factor: 4.280

7.  Regulation of pyruvate dehydrogenase kinase activity by protein thiol-disulfide exchange.

Authors:  F H Pettit; J Humphreys; L J Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

8.  Purification and partial characterization of a putative mediator of insulin action on cyclic AMP-dependent protein kinase.

Authors:  M P Thompson; J Larner; D L Kilpatrick
Journal:  Mol Cell Biochem       Date:  1984-04       Impact factor: 3.396

9.  Mechanisms of the fasting-induced dissociation of insulin binding from its action in isolated rat hepatocytes.

Authors:  M Trowbridge; A Sussman; L Ferguson; B Draznin; N Neufeld; N Begum; H Tepperman; J Tepperman
Journal:  Mol Cell Biochem       Date:  1984-04       Impact factor: 3.396

10.  Defective insulin response of cyclic adenosine monophosphate-dependent protein kinase in insulin-resistant humans.

Authors:  Y Kida; B L Nyomba; C Bogardus; D M Mott
Journal:  J Clin Invest       Date:  1991-02       Impact factor: 14.808
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