Hugo Peyre1, Mario Speranza2, Samuele Cortese3, Mathias Wohl4, Diane Purper-Ouakil5. 1. INSERM U669, University Paris-Sud and University Paris Descartes, Paris, France Robert Debré Hospital, Paris, France peyrehugo@yahoo.fr. 2. INSERM U669, University Paris-Sud and University Paris Descartes, Paris, France Versailles General Hospital. Le Chesnay, France University of Versailles Saint-Quentin-en-Yvelines, Versailles, France. 3. University Hospital, Tours, France New York University Child Study Center, New York, USA INSERM U894, University Paris Descartes, Paris, France. 4. INSERM U894, University Paris Descartes, Paris, France Louis Mourier Hospital, Colombes, France. 5. Robert Debré Hospital, Paris, France INSERM U894, University Paris Descartes, Paris, France.
Abstract
OBJECTIVE: The Child Behavior Checklist-Dysregulation Profile (CBCL-DP), characterized by elevated scores on the "Attention Problems," "Aggressive Behavior," and "Anxious/Depressed" scales in the CBCL, has been associated with later severe psychopathology. In a sample of children with ADHD, this study sought to further explore the clinical characteristics, the response to methylphenidate medication, and the cognitive features of ADHD children with CBCL-DP. METHOD: The sample consisted of 173 ADHD outpatients (age = 10.9 ± 2.81) assessed using symptom severity scales, personality questionnaires (Emotionality Activity Sociability [EAS] and Junior Temperament and Character Inventory [JTCI]), and neuropsychological tests. A subsample of 136 participants was reassessed after optimal adjustment of methylphenidate dosage. RESULTS AND CONCLUSION: Variables that were independently associated with CBCL-DP were clinical severity (ADHD Rating Scale [ADHD-RS]), internalized disorders, high emotionality (EAS), and low self-directedness (JTCI). CBCL-DP was associated neither with poorer response to methylphenidate nor with more side effects. There were no differences in cognitive performances between participants with and without CBCL-DP.
OBJECTIVE: The Child Behavior Checklist-Dysregulation Profile (CBCL-DP), characterized by elevated scores on the "Attention Problems," "Aggressive Behavior," and "Anxious/Depressed" scales in the CBCL, has been associated with later severe psychopathology. In a sample of children with ADHD, this study sought to further explore the clinical characteristics, the response to methylphenidate medication, and the cognitive features of ADHDchildren with CBCL-DP. METHOD: The sample consisted of 173 ADHD outpatients (age = 10.9 ± 2.81) assessed using symptom severity scales, personality questionnaires (Emotionality Activity Sociability [EAS] and Junior Temperament and Character Inventory [JTCI]), and neuropsychological tests. A subsample of 136 participants was reassessed after optimal adjustment of methylphenidate dosage. RESULTS AND CONCLUSION: Variables that were independently associated with CBCL-DP were clinical severity (ADHD Rating Scale [ADHD-RS]), internalized disorders, high emotionality (EAS), and low self-directedness (JTCI). CBCL-DP was associated neither with poorer response to methylphenidate nor with more side effects. There were no differences in cognitive performances between participants with and without CBCL-DP.
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