Literature DB >> 228373

Auditory arousal thresholds of good sleepers and poor sleepers with and without flurazepam.

L C Johnson, M W Church, D M Seales, V S Rossiter.   

Abstract

Auditory arousal thresholds of good (N = 12) and poor (N = 12) sleepers (sleep onset insomniacs) were obtained during stage 2, stage 4, and REM sleep at various times of the night. Despite claims of being "light" sleepers who are easily awakened by noise, poor sleeper auditory arousal thresholds were the same as those of good sleepers. Flurazepam (30 mg) increased the auditory arousal thresholds of poor sleepers (N = 6), but the increase was statistically significant only during the period of peak effect which occurred 1--2 hr after ingestion. Consistent with poor sleeper complaints of trouble falling asleep, the return to sleep (i.e., sleep latency) was significantly longer for poor than for good sleepers following stimulus arousals during the first stage 2 and first stage 4 periods of the night. Sleep latencies for good and poor sleepers did not differ significantly following subsequent arousals. The sleep latency following the first stage 2 stimulus arousal was significantly reduced in poor sleepers during flurazepam-induced sleep.

Entities:  

Mesh:

Substances:

Year:  1979        PMID: 228373     DOI: 10.1093/sleep/1.3.259

Source DB:  PubMed          Journal:  Sleep        ISSN: 0161-8105            Impact factor:   5.849


  5 in total

1.  Dose level effects of triazolam on sleep and response to a smoke detector alarm.

Authors:  L C Johnson; C L Spinweber; S C Webb; A G Muzet
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  L-tryptophan administered to chronic sleep-onset insomniacs: late-appearing reduction of sleep latency.

Authors:  C L Spinweber
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

3.  Can the Orexin Antagonist Suvorexant Preserve the Ability to Awaken to Auditory Stimuli While Improving Sleep?

Authors:  Christopher L Drake; David A Kalmbach; Philip Cheng; Thomas Roth; Kieulinh Michelle Tran; Andrea Cuamatzi-Castelan; Rachel Atkinson; Meeta Singh; Christine V Tonnu; Cynthia Fellman-Couture
Journal:  J Clin Sleep Med       Date:  2019-09-15       Impact factor: 4.062

4.  Effects of brotizolam, flurazepam and placebo upon nocturnal auditory arousal thresholds.

Authors:  K M Hartse; J I Thornby; I Karacan; R L Williams
Journal:  Br J Clin Pharmacol       Date:  1983       Impact factor: 4.335

5.  Effects of flurazepam on sleep, arousal threshold, and the perception of being asleep.

Authors:  W B Mendelson; J V Martin; H Stephens; H Giesen; S P James
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.