Literature DB >> 22837213

Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci.

Jelke J Fros1, Natalia E Domeradzka, Jim Baggen, Corinne Geertsema, Jacky Flipse, Just M Vlak, Gorben P Pijlman.   

Abstract

Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A conserved SH3 domain-binding motif in nsP3 is essential for both nsP3-G3BP interactions and viral RNA replication. This study reveals a novel role for nsP3 as a regulator of the cellular stress response.

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Year:  2012        PMID： 22837213      PMCID： PMC3457282          DOI： 10.1128/JVI.01506-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

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2.  Stress granules.

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3.  Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling.

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4.  Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication.

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Journal:  J Virol       Date:  2010-09-15       Impact factor: 5.103

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Authors:  Olivier Schwartz; Matthew L Albert
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Journal:  PLoS Pathog       Date:  2011-11-17       Impact factor: 6.823

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  83 in total

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Authors:  Jelke J Fros; Erika van der Maten; Just M Vlak; Gorben P Pijlman
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5.  Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation.

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6.  Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.

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10.  Cytoplasmic RNA Granules and Viral Infection.

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Journal:  Annu Rev Virol       Date:  2014-11       Impact factor: 10.431
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