Literature DB >> 22837211

The secreted G protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement.

Alexander Bukreyev1, Lijuan Yang, Peter L Collins.   

Abstract

The respiratory syncytial virus (RSV) G and F glycoproteins are the neutralization antigens, and G also is expressed in a soluble form (sG). Previously, sG was demonstrated to reduce the efficiency of RSV antibody-mediated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes. The present study demonstrated that effective antibody-mediated restriction in vivo, and the evasion of this restriction by sG, involves pulmonary macrophages and complement, but not neutrophils.

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Year:  2012        PMID： 22837211      PMCID： PMC3457292          DOI： 10.1128/JVI.01162-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Control of early viral and bacterial distribution and disease by natural antibodies.

Authors:  A F Ochsenbein; T Fehr; C Lutz; M Suter; F Brombacher; H Hengartner; R M Zinkernagel
Journal:  Science       Date:  1999-12-10       Impact factor: 47.728

2.  A novel role for neutrophils as critical activators of NK cells.

Authors:  Roman Spörri; Nicole Joller; Hubert Hilbi; Annette Oxenius
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

3.  Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells.

Authors:  A Bukreyev; I M Belyakov; J A Berzofsky; B R Murphy; P L Collins
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

4.  Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivo.

Authors:  M N Teng; S S Whitehead; P L Collins
Journal:  Virology       Date:  2001-10-25       Impact factor: 3.616

5.  Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development.

Authors:  Philippa K Pribul; James Harker; Belinda Wang; Hongwei Wang; John S Tregoning; Jürgen Schwarze; Peter J M Openshaw
Journal:  J Virol       Date:  2008-02-20       Impact factor: 5.103

6.  Neonatal respiratory syncytial virus infection.

Authors:  C B Hall; A E Kopelman; R G Douglas; J M Geiman; M P Meagher
Journal:  N Engl J Med       Date:  1979-02-22       Impact factor: 91.245

7.  Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

Authors:  Yutaro Kumagai; Osamu Takeuchi; Hiroki Kato; Himanshu Kumar; Kosuke Matsui; Eiichi Morii; Katsuyuki Aozasa; Taro Kawai; Shizuo Akira
Journal:  Immunity       Date:  2007-08       Impact factor: 31.745

8.  The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes.

Authors:  Alexander Bukreyev; Lijuan Yang; Jens Fricke; Lily Cheng; Jerrold M Ward; Brian R Murphy; Peter L Collins
Journal:  J Virol       Date:  2008-10-08       Impact factor: 5.103

9.  The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines.

Authors:  Peter F Wright; Ruth A Karron; Robert B Belshe; Jian R Shi; Valerie B Randolph; Peter L Collins; Alice F O'Shea; William C Gruber; Brian R Murphy
Journal:  Vaccine       Date:  2007-08-28       Impact factor: 3.641

10.  H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.

Authors:  Lucy A Perrone; Julie K Plowden; Adolfo García-Sastre; Jacqueline M Katz; Terrence M Tumpey
Journal:  PLoS Pathog       Date:  2008-08-01       Impact factor: 6.823
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  28 in total

1.  Effects of Alterations to the CX3C Motif and Secreted Form of Human Respiratory Syncytial Virus (RSV) G Protein on Immune Responses to a Parainfluenza Virus Vector Expressing the RSV G Protein.

Authors:  Bo Liang; Barbora Kabatova; Juraj Kabat; David W Dorward; Xiang Liu; Sonja Surman; Xueqiao Liu; Annie Park Moseman; Ursula J Buchholz; Peter L Collins; Shirin Munir
Journal:  J Virol       Date:  2019-03-21       Impact factor: 5.103

2.  Partial Attenuation of Respiratory Syncytial Virus with a Deletion of a Small Hydrophobic Gene Is Associated with Elevated Interleukin-1β Responses.

Authors:  Ryan F Russell; Jacqueline U McDonald; Maria Ivanova; Ziyun Zhong; Alexander Bukreyev; John S Tregoning
Journal:  J Virol       Date:  2015-06-17       Impact factor: 5.103

3.  Glycosylation of Antigen-Specific Antibodies: Perspectives on Immunoglobulin G Glycosylation in Vaccination and Immunotherapy.

Authors:  Pranay Bharadwaj; Margaret E Ackerman
Journal:  Exp Suppl       Date:  2021

Review 4.  Structure and function of respiratory syncytial virus surface glycoproteins.

Authors:  Jason S McLellan; William C Ray; Mark E Peeples
Journal:  Curr Top Microbiol Immunol       Date:  2013       Impact factor: 4.291

5.  Functional correlations of respiratory syncytial virus proteins to intrinsic disorder.

Authors:  Jillian N Whelan; Krishna D Reddy; Vladimir N Uversky; Michael N Teng
Journal:  Mol Biosyst       Date:  2016-04-26

Review 6.  Antibody-mediated complement activation in pathology and protection.

Authors:  Benjamin S Goldberg; Margaret E Ackerman
Journal:  Immunol Cell Biol       Date:  2020-04-06       Impact factor: 5.126

7.  Respiratory syncytial virus G protein CX3C motif impairs human airway epithelial and immune cell responses.

Authors:  Tatiana Chirkova; Seyhan Boyoglu-Barnum; Kelsey A Gaston; Fahad M Malik; Steven P Trau; Antonius G P Oomens; Larry J Anderson
Journal:  J Virol       Date:  2013-10-02       Impact factor: 5.103

8.  A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.

Authors:  Stacey Human; Anne L Hotard; Larry J Anderson; Tina V Hartert; Martin L Moore; Christina A Rostad; Sujin Lee; Louise McCormick; Emma K Larkin; Teresa C T Peret; Jaume Jorba; Joseph Lanzone; Tebeb Gebretsadik; John V Williams; Melissa Bloodworth; Matthew Stier; Kecia Carroll; R Stokes Peebles
Journal:  J Virol       Date:  2020-12-22       Impact factor: 5.103

Review 9.  Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity.

Authors:  Jop Jans; Marloes Vissers; Jacco G M Heldens; Marien I de Jonge; Ofer Levy; Gerben Ferwerda
Journal:  Rev Med Virol       Date:  2013-11-14       Impact factor: 6.989

Review 10.  Respiratory Syncytial Virus: Targeting the G Protein Provides a New Approach for an Old Problem.

Authors:  Ralph A Tripp; Ultan F Power; Peter J M Openshaw; Lawrence M Kauvar
Journal:  J Virol       Date:  2018-01-17       Impact factor: 5.103
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