RATIONALE: Both glutamate and serotonin (5-HT) play a key role in the pathophysiology of emotional biases. Recent studies indicate that the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine and the 5-HT receptor agonist psilocybin are implicated in emotion processing. However, as yet, no study has systematically compared their contribution to emotional biases. OBJECTIVES: This study used event-related potentials (ERPs) and signal detection theory to compare the effects of the NMDA (via S-ketamine) and 5-HT (via psilocybin) receptor system on non-conscious or conscious emotional face processing biases. METHODS:S-ketamine or psilocybin was administrated to two groups of healthy subjects in a double-blind within-subject placebo-controlled design. We behaviorally assessed objective thresholds for non-conscious discrimination in all drug conditions. Electrophysiological responses to fearful, happy, and neutral faces were subsequently recorded with the face-specific P100 and N170 ERP. RESULTS: Both S-ketamine and psilocybin impaired the encoding of fearful faces as expressed by a reduced N170 over parieto-occipital brain regions. In contrast, while S-ketamine also impaired the encoding of happy facial expressions, psilocybin had no effect on the N170 in response to happy faces. CONCLUSION: This study demonstrates that the NMDA and 5-HT receptor systems differentially contribute to the structural encoding of emotional face expressions as expressed by the N170. These findings suggest that the assessment of early visual evoked responses might allow detecting pharmacologically induced changes in emotional processing biases and thus provides a framework to study the pathophysiology of dysfunctional emotional biases.
RCT Entities:
RATIONALE: Both glutamate and serotonin (5-HT) play a key role in the pathophysiology of emotional biases. Recent studies indicate that the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine and the 5-HT receptor agonist psilocybin are implicated in emotion processing. However, as yet, no study has systematically compared their contribution to emotional biases. OBJECTIVES: This study used event-related potentials (ERPs) and signal detection theory to compare the effects of the NMDA (via S-ketamine) and 5-HT (via psilocybin) receptor system on non-conscious or conscious emotional face processing biases. METHODS:S-ketamine or psilocybin was administrated to two groups of healthy subjects in a double-blind within-subject placebo-controlled design. We behaviorally assessed objective thresholds for non-conscious discrimination in all drug conditions. Electrophysiological responses to fearful, happy, and neutral faces were subsequently recorded with the face-specific P100 and N170 ERP. RESULTS: Both S-ketamine and psilocybin impaired the encoding of fearful faces as expressed by a reduced N170 over parieto-occipital brain regions. In contrast, while S-ketamine also impaired the encoding of happy facial expressions, psilocybin had no effect on the N170 in response to happy faces. CONCLUSION: This study demonstrates that the NMDA and 5-HT receptor systems differentially contribute to the structural encoding of emotional face expressions as expressed by the N170. These findings suggest that the assessment of early visual evoked responses might allow detecting pharmacologically induced changes in emotional processing biases and thus provides a framework to study the pathophysiology of dysfunctional emotional biases.
Authors: Hannah Schoch; Arati S Kreibich; Sarah L Ferri; Rachel S White; Dominique Bohorquez; Anamika Banerjee; Russell G Port; Holly C Dow; Lucero Cordero; Ashley A Pallathra; Hyong Kim; Hongzhe Li; Warren B Bilker; Shinji Hirano; Robert T Schultz; Karin Borgmann-Winter; Chang-Gyu Hahn; Dirk Feldmeyer; Gregory C Carlson; Ted Abel; Edward S Brodkin Journal: Biol Psychiatry Date: 2016-06-16 Impact factor: 13.382
Authors: Theresa M Carbonaro; Matthew W Johnson; Ethan Hurwitz; Roland R Griffiths Journal: Psychopharmacology (Berl) Date: 2017-11-07 Impact factor: 4.530
Authors: Katrin H Preller; Thomas Pokorny; Andreas Hock; Rainer Kraehenmann; Philipp Stämpfli; Erich Seifritz; Milan Scheidegger; Franz X Vollenweider Journal: Proc Natl Acad Sci U S A Date: 2016-04-18 Impact factor: 11.205
Authors: Rainer Kraehenmann; André Schmidt; Karl Friston; Katrin H Preller; Erich Seifritz; Franz X Vollenweider Journal: Neuroimage Clin Date: 2015-08-22 Impact factor: 4.881
Authors: Thomas Pokorny; Katrin H Preller; Michael Kometer; Isabel Dziobek; Franz X Vollenweider Journal: Int J Neuropsychopharmacol Date: 2017-09-01 Impact factor: 5.176
Authors: F Mueller; C Lenz; P C Dolder; S Harder; Y Schmid; U E Lang; M E Liechti; S Borgwardt Journal: Transl Psychiatry Date: 2017-04-04 Impact factor: 6.222