Literature DB >> 22835872

Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors.

Argyro Vontzalidou1, Grigoris Zoidis, Eliza Chaita, Maria Makropoulou, Nektarios Aligiannis, George Lambrinidis, Emmanuel Mikros, Alexios-Leandros Skaltsounis.   

Abstract

The synthesis, molecular modeling and biological evaluation of substituted deoxybenzoins and optimized dihydrostilbenes are reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered. Dihydrostilbene 7 is a particularly potent inhibitor (IC(50)=8.44 μM, more potent than kojic acid).
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22835872     DOI： 10.1016/j.bmcl.2012.07.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers.

Authors:  Tze Han Sum; Tze Jing Sum; Warren R J D Galloway; Súil Collins; David G Twigg; Florian Hollfelder; David R Spring
Journal:  Molecules       Date:  2016-09-16       Impact factor: 4.411

2.  In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme.

Authors:  Azizeh Asadzadeh; Hajar Sirous; Morteza Pourfarzam; Parichehreh Yaghmaei; Fassihi Afshin
Journal:  Iran J Basic Med Sci       Date:  2016-02       Impact factor: 2.699

3.  Estimation of Inhibitory Effect against Tyrosinase Activity through Homology Modeling and Molecular Docking.

Authors:  Daungkamon Nokinsee; Lalida Shank; Vannajan Sanghiran Lee; Piyarat Nimmanpipug
Journal:  Enzyme Res       Date:  2015-12-15

Review 4.  Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.

Authors:  Thanigaimalai Pillaiyar; Manoj Manickam; Vigneshwaran Namasivayam
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

5.  Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.

Authors:  Eliza Chaita; George Lambrinidis; Christina Cheimonidi; Adamantia Agalou; Dimitris Beis; Ioannis Trougakos; Emmanuel Mikros; Alexios-Leandros Skaltsounis; Nektarios Aligiannis
Journal:  Molecules       Date:  2017-03-23       Impact factor: 4.411

6.  Development of Stilbenoid and Chalconoid Analogues as Potent Tyrosinase Modulators and Antioxidant Agents.

Authors:  Argyro Vontzalidou; Sapfo-Maria Dimitrakoudi; Konstantinos Tsoukalas; Grigoris Zoidis; Eliza Chaita; Evanthia Dina; Christina Cheimonidi; Ioannis P Trougakos; George Lambrinidis; Alexios-Leandros Skaltsounis; Emmanuel Mikros; Nektarios Aligiannis
Journal:  Antioxidants (Basel)       Date:  2022-08-17

7.  Novel 1,2,4-triazole analogues as mushroom tyrosinase inhibitors: synthesis, kinetic mechanism, cytotoxicity and computational studies.

Authors:  Balasaheb D Vanjare; Prasad G Mahajan; Nilam C Dige; Hussain Raza; Mubashir Hassan; Yohan Han; Song Ja Kim; Sung-Yum Seo; Ki Hwan Lee
Journal:  Mol Divers       Date:  2020-05-12       Impact factor: 2.943

8.  Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors.

Authors:  Qi Li; Hongyu Yang; Jun Mo; Yao Chen; Yue Wu; Chen Kang; Yuan Sun; Haopeng Sun
Journal:  PeerJ       Date:  2018-01-26       Impact factor: 2.984

Review 9.  A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery.

Authors:  Thanigaimalai Pillaiyar; Sangeetha Meenakshisundaram; Manoj Manickam; Murugesan Sankaranarayanan
Journal:  Eur J Med Chem       Date:  2020-04-02       Impact factor: 6.514

10.  Jeju Magma-Seawater Inhibits α-MSH-Induced Melanogenesis via CaMKKβ-AMPK Signaling Pathways in B16F10 Melanoma Cells.

Authors:  Minhyeok Song; Jihyun Lee; Young-Joo Kim; Dang Hieu Hoang; Wonchae Choe; Insug Kang; Sung Soo Kim; Joohun Ha
Journal:  Mar Drugs       Date:  2020-09-18       Impact factor: 5.118
  10 in total

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