Amal Shohayeb1, Waleed El-Khayat. 1. IVF Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt; Samir Abbas IVF Center, Jeddah, Saudi Arabia.
Abstract
OBJECTIVE: To evaluate the effect of a single endometrial biopsy regimen (S-EBR) in the cycle preceding the ICSI cycle in patients with repeated implantation failure. STUDY DESIGN: This was a prospective randomized controlled trial which included two-hundred infertile women with a history of repeated implantation failure. The subjects were randomly divided into two groups. Group A subjects underwent hysteroscopy and endometrial scraping by Novak curette in the cycle preceding the ICSI cycle, while group B subjects underwent hysteroscopy without endometrial scraping. Implantation rate, clinical pregnancy rate, abortion rate and live birth rate were compared between both groups. RESULTS: The number of retrieved oocytes in group A was 11.6 ± 3 and in group B was 11.6 ± 2.8 with no statistically significant difference (p=0.787). There were statistically significant differences regarding the implantation rate, the clinical pregnancy rate and live birth rate. The implantation rate in group A was 12% while in group B it was 7% (p=0.015), the clinical pregnancy rate was 32% in group A while it was only 18% in group B (p=0.034) and the live birth rate was 28% in group A while it was 14% in group B (p=0.024). CONCLUSIONS: The single endometrial biopsy regimen (S-EBR) performed during hysteroscopy has statistically significant higher implantation rate, clinical pregnancy rate and live birth rate than hysteroscopy without endometrial scraping.
RCT Entities:
OBJECTIVE: To evaluate the effect of a single endometrial biopsy regimen (S-EBR) in the cycle preceding the ICSI cycle in patients with repeated implantation failure. STUDY DESIGN: This was a prospective randomized controlled trial which included two-hundred infertile women with a history of repeated implantation failure. The subjects were randomly divided into two groups. Group A subjects underwent hysteroscopy and endometrial scraping by Novak curette in the cycle preceding the ICSI cycle, while group B subjects underwent hysteroscopy without endometrial scraping. Implantation rate, clinical pregnancy rate, abortion rate and live birth rate were compared between both groups. RESULTS: The number of retrieved oocytes in group A was 11.6 ± 3 and in group B was 11.6 ± 2.8 with no statistically significant difference (p=0.787). There were statistically significant differences regarding the implantation rate, the clinical pregnancy rate and live birth rate. The implantation rate in group A was 12% while in group B it was 7% (p=0.015), the clinical pregnancy rate was 32% in group A while it was only 18% in group B (p=0.034) and the live birth rate was 28% in group A while it was 14% in group B (p=0.024). CONCLUSIONS: The single endometrial biopsy regimen (S-EBR) performed during hysteroscopy has statistically significant higher implantation rate, clinical pregnancy rate and live birth rate than hysteroscopy without endometrial scraping.
Authors: N E van Hoogenhuijze; H L Torrance; F Mol; J S E Laven; E Scheenjes; M A F Traas; C Janssen; B Cohlen; G Teklenburg; J P de Bruin; R van Oppenraaij; J W M Maas; E Moll; K Fleischer; M H van Hooff; C de Koning; A Cantineau; C B Lambalk; M Verberg; M Nijs; A P Manger; M van Rumste; L F van der Voet; A Preys-Bosman; J Visser; E Brinkhuis; J E den Hartog; A Sluijmer; F W Jansen; W Hermes; M L Bandell; M J Pelinck; J van Disseldorp; M van Wely; J Smeenk; Q D Pieterse; J C Boxmeer; E R Groenewoud; M J C Eijkemans; J C Kasius; F J M Broekmans Journal: BMC Womens Health Date: 2017-07-21 Impact factor: 2.809
Authors: Sarah F Lensen; Sarah Armstrong; Ahmed Gibreel; Carolina O Nastri; Nick Raine-Fenning; Wellington P Martins Journal: Cochrane Database Syst Rev Date: 2021-06-10