| Literature DB >> 22835544 |
Reuben H Kim1, Shebli Mehrazarin, Mo K Kang.
Abstract
Mesenchymal stem cells (MSCs) are adult stem cells whose self-renewal, multipotency, and immunosuppressive functions have been investigated for therapeutic applications. MSCs have used for various systemic organ regenerative therapies, allowing rescue of tissue function in damaged or failing organs. This article reviews the regenerative and immunomodulatory functions of MSCs and their applications in dental, orofacial, and systemic tissue regeneration and treatment of inflammatory disorders. It also addresses challenges to MSC-mediated therapeutics arising from tissue and MSC aging and host immune response against allogenic MSC transplantation, and discusses alternative sources of MSCs aimed at overcoming these limitations.Entities:
Mesh:
Year: 2012 PMID: 22835544 PMCID: PMC3426923 DOI: 10.1016/j.cden.2012.05.006
Source DB: PubMed Journal: Dent Clin North Am ISSN: 0011-8532