| Literature DB >> 22835457 |
Maggie K Diamond-Stanic1, Young H You, Kumar Sharma.
Abstract
TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.Entities:
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Year: 2012 PMID: 22835457 PMCID: PMC3442601 DOI: 10.1016/j.semnephrol.2012.04.005
Source DB: PubMed Journal: Semin Nephrol ISSN: 0270-9295 Impact factor: 5.299