Lisa Wyman1, Rosa M Crum, David Celentano. 1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Abstract
PURPOSE: The current study describes how the excess mortality risk associated with depression translates into specific causes of death occurring during a 40-year follow-up period, with focus on deaths related to injuries, cardiovascular diseases, and cancer. METHODS: Data come from a cross-sectional survey (Community Mental Health Epidemiology Study) conducted in the early 1970s in Washington County, Maryland. Random sampling for the survey resulted in 2762 interviews. For the current analyses, baseline depressed mood was linked to current participant vital status through the use of death certificates. RESULTS: The relative subdistribution hazards for cardiovascular deaths (3.08 [1.74-5.45]) and fatal injuries (4.63 [1.76-12.18]) were significant during the entire 40-year period for young adults (18-39 years old at baseline). The relative subdistribution hazard for cardiovascular deaths during the first 15 years of follow-up was pronounced in elderly (≥ 65 years) males (2.99 [1.67-5.37]) subjects. There were no significant associations between depressed mood and cancer deaths. CONCLUSIONS: Individuals in the general community with depressed mood may be at increased risk of deaths as the result of cardiovascular disease and injury, even several decades after exposure assessment. Young adults with depressed mood appear to be particularly vulnerable to these associations.
PURPOSE: The current study describes how the excess mortality risk associated with depression translates into specific causes of death occurring during a 40-year follow-up period, with focus on deaths related to injuries, cardiovascular diseases, and cancer. METHODS: Data come from a cross-sectional survey (Community Mental Health Epidemiology Study) conducted in the early 1970s in Washington County, Maryland. Random sampling for the survey resulted in 2762 interviews. For the current analyses, baseline depressed mood was linked to current participant vital status through the use of death certificates. RESULTS: The relative subdistribution hazards for cardiovascular deaths (3.08 [1.74-5.45]) and fatal injuries (4.63 [1.76-12.18]) were significant during the entire 40-year period for young adults (18-39 years old at baseline). The relative subdistribution hazard for cardiovascular deaths during the first 15 years of follow-up was pronounced in elderly (≥ 65 years) males (2.99 [1.67-5.37]) subjects. There were no significant associations between depressed mood and cancer deaths. CONCLUSIONS: Individuals in the general community with depressed mood may be at increased risk of deaths as the result of cardiovascular disease and injury, even several decades after exposure assessment. Young adults with depressed mood appear to be particularly vulnerable to these associations.
Authors: David J Vinkers; Max L Stek; Jacobijn Gussekloo; Roos C Van Der Mast; Rudi G J Westendorp Journal: Int J Geriatr Psychiatry Date: 2004-09 Impact factor: 3.485
Authors: Viola Vaccarino; Amit J Shah; Cherie Rooks; Ijeoma Ibeanu; Jonathon A Nye; Pratik Pimple; Amy Salerno; Luis D'Marco; Cristina Karohl; James Douglas Bremner; Paolo Raggi Journal: Psychosom Med Date: 2014-04 Impact factor: 4.312
Authors: Lena Mathews; Oluseye Ogunmoroti; Khurram Nasir; Roger S Blumenthal; Ovie A Utuama; Maribeth Rouseff; Sankalp Das; Emir Veledar; Theodore Feldman; Arthur Agatston; Di Zhao; Erin D Michos Journal: J Womens Health (Larchmt) Date: 2018-01-29 Impact factor: 2.681
Authors: Viola Vaccarino; Samaah Sullivan; Muhammad Hammadah; Kobina Wilmot; Ibhar Al Mheid; Ronnie Ramadan; Lisa Elon; Pratik M Pimple; Ernest V Garcia; Jonathon Nye; Amit J Shah; Ayman Alkhoder; Oleksiy Levantsevych; Hawkins Gay; Malik Obideen; Minxuan Huang; Tené T Lewis; J Douglas Bremner; Arshed A Quyyumi; Paolo Raggi Journal: Circulation Date: 2018-02-20 Impact factor: 29.690
Authors: Daniel F Hermens; Elizabeth M Scott; Django White; Marta Lynch; Jim Lagopoulos; Bradley G Whitwell; Sharon L Naismith; Ian B Hickie Journal: BMJ Open Date: 2013-02-04 Impact factor: 2.692