Literature DB >> 22834013

Exploiting nutrient transporters at the blood-brain barrier to improve brain distribution of small molecules.

Rajendar K Mittapalli1, Vamshi K Manda, Chris E Adkins, Werner J Geldenhuys, Paul R Lockman.   

Abstract

The blood-brain barrier (BBB) is a major physiological barrier for drugs that target CNS receptors or enzymes. Several methods exist by which permeability to the CNS can be increased, one of which is using native nutrient transporters to carry these drugs through the endothelial cells of the BBB. In this review, we focus on work that characterizes the use of nutrient transporters of the BBB in delivering drugs to the CNS.

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Year:  2010        PMID： 22834013     DOI： 10.4155/tde.10.76

Source DB:  PubMed          Journal:  Ther Deliv        ISSN： 2041-5990


  10 in total

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  10 in total

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