Literature DB >> 2283136

Cocaine fatality: an unexplained blood concentration in a fatal overdose.

F J Peretti1, D S Isenschmid, B Levine, Y H Caplan, J E Smialek.   

Abstract

A case is presented of a 26-year-old female who died as a result of cocaine intoxication. A blood cocaine concentration of 330 mg/l, about 1.5 times greater than the highest concentration previously reported, was found. Blood benzoylecgonine and ecgonine methyl ester concentrations were 50 and 18 mg/l, respectively. The unusually high blood concentrations of cocaine and the metabolites are suggestive of a massive administration, however, the history suggests a series of recreational uses. The manner of death was undetermined.

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Year:  1990        PMID: 2283136     DOI: 10.1016/0379-0738(90)90105-8

Source DB:  PubMed          Journal:  Forensic Sci Int        ISSN: 0379-0738            Impact factor:   2.395


  13 in total

1.  Mechanisms of acute cocaine toxicity.

Authors:  Kennon Heard; Robert Palmer; Nancy R Zahniser
Journal:  Open Pharmacol J       Date:  2008

2.  Normal and atypical butyrylcholinesterases in placental development, function, and malfunction.

Authors:  M Sternfeld; J Rachmilewitz; Y Loewenstein-Lichtenstein; C Andres; R Timberg; S Ben-Ari; C Glick; H Soreq; H Zakut
Journal:  Cell Mol Neurobiol       Date:  1997-06       Impact factor: 5.046

3.  Cocaine enhances HIV-1-induced CD4(+) T-cell apoptosis: implications in disease progression in cocaine-abusing HIV-1 patients.

Authors:  Jui Pandhare; Amma B Addai; Chinmay K Mantri; Cynthia Hager; Rita M Smith; Louis Barnett; Fernando Villalta; Spyros A Kalams; Chandravanu Dash
Journal:  Am J Pathol       Date:  2014-01-31       Impact factor: 4.307

4.  Cocaine modulates HIV-1 integration in primary CD4+ T cells: implications in HIV-1 pathogenesis in drug-abusing patients.

Authors:  Amma B Addai; Jui Pandhare; Victor Paromov; Chinmay K Mantri; Siddharth Pratap; Chandravanu Dash
Journal:  J Leukoc Biol       Date:  2015-02-17       Impact factor: 4.962

5.  Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine.

Authors:  Emiliano J Sanchez; Robert P Hayes; John T Barr; Kevin M Lewis; Brian N Webb; Arun K Subramanian; Mark S Nissen; Jeffrey P Jones; Eric A Shelden; Barbara A Sorg; Michael Fill; James O Schenk; Chulhee Kang
Journal:  Drug Alcohol Depend       Date:  2013-07-19       Impact factor: 4.492

6.  Cocaine-Mediated Autophagy in Astrocytes Involves Sigma 1 Receptor, PI3K, mTOR, Atg5/7, Beclin-1 and Induces Type II Programed Cell Death.

Authors:  Lu Cao; Mary P Walker; Naveen K Vaidya; Mingui Fu; Santosh Kumar; Anil Kumar
Journal:  Mol Neurobiol       Date:  2015-08-05       Impact factor: 5.590

7.  Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b.

Authors:  Sabyasachi Dash; Muthukumar Balasubramaniam; Tanu Rana; Arthur Godino; Emily G Peck; Jeffery Shawn Goodwin; Fernando Villalta; Erin S Calipari; Eric J Nestler; Chandravanu Dash; Jui Pandhare
Journal:  eNeuro       Date:  2017-08-18

Review 8.  Coca: The History and Medical Significance of an Ancient Andean Tradition.

Authors:  Amy Sue Biondich; Jeremy David Joslin
Journal:  Emerg Med Int       Date:  2016-04-07       Impact factor: 1.112

9.  Cocaine Enhances HIV-1 Transcription in Macrophages by Inducing p38 MAPK Phosphorylation.

Authors:  Chelsie Swepson; Alok Ranjan; Muthukumar Balasubramaniam; Jui Pandhare; Chandravanu Dash
Journal:  Front Microbiol       Date:  2016-06-09       Impact factor: 5.640

10.  Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review.

Authors:  Fabien Bévalot; Nathalie Cartiser; Charline Bottinelli; Laurent Fanton; Jérôme Guitton
Journal:  Forensic Toxicol       Date:  2015-10-28       Impact factor: 4.096

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