BACKGROUND: The novel pandemic influenza A (H1N1) 2009 virus (influenza A(H1N1)pdm09) caused an epidemic of critical illness, with some patients developing fatal encephalopathy as well as pneumonia. METHODS: To investigate the actual efficacy of treatments, we investigated data from questionnaires regarding 207 cases that occurred between September 2009 and February 2010. RESULTS: The outcomes were recorded in 188 of the 207 cases; 16 of 188 patients died, while 23 had sequelae. Anti-influenza drugs in patients with severe coma (Glasgow coma scale score of ≤ 8) were statistically effective. In 165 out of 199 cases, steroid pulse treatment with methylprednisolone was given at an early stage. Other intensive treatments were mostly administered in serious cases. CONCLUSIONS: Controlled studies are needed to investigate the efficacy of other treatments except for anti-influenza drugs.
BACKGROUND: The novel pandemic influenza A (H1N1) 2009 virus (influenza A(H1N1)pdm09) caused an epidemic of critical illness, with some patients developing fatal encephalopathy as well as pneumonia. METHODS: To investigate the actual efficacy of treatments, we investigated data from questionnaires regarding 207 cases that occurred between September 2009 and February 2010. RESULTS: The outcomes were recorded in 188 of the 207 cases; 16 of 188 patients died, while 23 had sequelae. Anti-influenza drugs in patients with severe coma (Glasgow coma scale score of ≤ 8) were statistically effective. In 165 out of 199 cases, steroid pulse treatment with methylprednisolone was given at an early stage. Other intensive treatments were mostly administered in serious cases. CONCLUSIONS: Controlled studies are needed to investigate the efficacy of other treatments except for anti-influenza drugs.
Authors: Won Suk Choi; Ji Hyeon Baek; Yu Bin Seo; Sae Yoon Kee; Hye Won Jeong; Hee Young Lee; Byung Wook Eun; Eun Ju Choo; Jacob Lee; Young Keun Kim; Joon Young Song; Seong-Heon Wie; Jin Soo Lee; Hee Jin Cheong; Woo Joo Kim Journal: Korean J Intern Med Date: 2014-01-02 Impact factor: 2.884