Literature DB >> 22829434

Direct α-functionalization of saturated cyclic amines.

Emily A Mitchell1, Aldo Peschiulli, Nicolas Lefevre, Lieven Meerpoel, Bert U W Maes.   

Abstract

Recent advances in synthetic methods for the direct α-functionalization of saturated cyclic amines are described. Methods are categorized according to the in situ formed reactive intermediate (α-amino cation, α-amino anion, and α-amino radical). Transition-metal-catalyzed reactions involving other intermediates have been treated as a separate and fourth class.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID: 22829434     DOI: 10.1002/chem.201201539

Source DB:  PubMed          Journal:  Chemistry        ISSN: 0947-6539            Impact factor:   5.236


  76 in total

1.  SnAP reagents for the one-step synthesis of medium-ring saturated N-heterocycles from aldehydes.

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3.  Second-Generation Palladium Catalyst System for Transannular C-H Functionalization of Azabicycloalkanes.

Authors:  Pablo J Cabrera; Melissa Lee; Melanie S Sanford
Journal:  J Am Chem Soc       Date:  2018-04-13       Impact factor: 15.419

4.  The Redox-A3 Reaction.

Authors:  Daniel Seidel
Journal:  Org Chem Front       Date:  2014-06-01       Impact factor: 5.281

5.  Redox-neutral α-arylation of amines.

Authors:  Weijie Chen; Richard G Wilde; Daniel Seidel
Journal:  Org Lett       Date:  2013-12-13       Impact factor: 6.005

6.  Highly Diastereoselective Functionalization of Piperidines by Photoredox-Catalyzed α-Amino C-H Arylation and Epimerization.

Authors:  Morgan M Walker; Brian Koronkiewicz; Shuming Chen; K N Houk; James M Mayer; Jonathan A Ellman
Journal:  J Am Chem Soc       Date:  2020-04-24       Impact factor: 15.419

7.  3-Aryl-2,5-Dihydropyrroles via Catalytic Carbonyl-Olefin Metathesis.

Authors:  Emilia J Groso; Alexander N Golonka; Ryan A Harding; Brandon W Alexander; Taylor M Sodano; Corinna S Schindler
Journal:  ACS Catal       Date:  2018-01-18       Impact factor: 13.084

8.  Electrochemical Aminoxyl-Mediated α-Cyanation of Secondary Piperidines for Pharmaceutical Building Block Diversification.

Authors:  Alastair J J Lennox; Shannon L Goes; Matthew P Webster; Hannes F Koolman; Stevan W Djuric; Shannon S Stahl
Journal:  J Am Chem Soc       Date:  2018-08-31       Impact factor: 15.419

9.  Iridium(I)-Catalyzed α-C(sp3)-H Alkylation of Saturated Azacycles.

Authors:  Pritha Verma; Jeremy M Richter; Nikita Chekshin; Jennifer X Qiao; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2020-03-09       Impact factor: 15.419

10.  Brønsted acid cocatalysts in photocatalytic radical addition of α-amino C-H bonds across Michael acceptors.

Authors:  Laura Ruiz Espelt; Eric M Wiensch; Tehshik P Yoon
Journal:  J Org Chem       Date:  2013-04-10       Impact factor: 4.354

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