PURPOSE: In this study, we investigated the effects of maternal transfer of bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) during gestational and weaning periods on gonadal development of male offspring. METHODS: Pregnant CD-1 mice were administered by gavages in corn oil with 0.1, 1, or 10 mg/kg/day of BPA and DEHP from gestational days (GD1-21) to the weaning period (postnatal days (PND) 1-21). RESULTS: Our data indicated that the exposure significantly reduced the male-to-female sex ratio and the sizes of the gonads of male pups as recorded at PND15. The testes of the perinatally exposed male pups were developed less and the expression levels of testicular anti-mullerian hormone, androgen receptor, cyclin A, and StAR were significantly lesser than the control male pups. The less developed testes were accompanied with significant reductions in the expression levels of Gnrh and Fsh at the hypothalamic-pituitary levels. The negative effects were found to be persistent in the sexually mature pups at PND42. CONCLUSION: Our data reveal that the maternal transfer of BPA and DEHP may impose negative influence on the development and functions of the reproductive system of male pups.
PURPOSE: In this study, we investigated the effects of maternal transfer of bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) during gestational and weaning periods on gonadal development of male offspring. METHODS: Pregnant CD-1 mice were administered by gavages in corn oil with 0.1, 1, or 10 mg/kg/day of BPA and DEHP from gestational days (GD1-21) to the weaning period (postnatal days (PND) 1-21). RESULTS: Our data indicated that the exposure significantly reduced the male-to-female sex ratio and the sizes of the gonads of male pups as recorded at PND15. The testes of the perinatally exposed male pups were developed less and the expression levels of testicular anti-mullerian hormone, androgen receptor, cyclin A, and StAR were significantly lesser than the control male pups. The less developed testes were accompanied with significant reductions in the expression levels of Gnrh and Fsh at the hypothalamic-pituitary levels. The negative effects were found to be persistent in the sexually mature pups at PND42. CONCLUSION: Our data reveal that the maternal transfer of BPA and DEHP may impose negative influence on the development and functions of the reproductive system of male pups.
Authors: Emma L Teuten; Jovita M Saquing; Detlef R U Knappe; Morton A Barlaz; Susanne Jonsson; Annika Björn; Steven J Rowland; Richard C Thompson; Tamara S Galloway; Rei Yamashita; Daisuke Ochi; Yutaka Watanuki; Charles Moore; Pham Hung Viet; Touch Seang Tana; Maricar Prudente; Ruchaya Boonyatumanond; Mohamad P Zakaria; Kongsap Akkhavong; Yuko Ogata; Hisashi Hirai; Satoru Iwasa; Kaoruko Mizukawa; Yuki Hagino; Ayako Imamura; Mahua Saha; Hideshige Takada Journal: Philos Trans R Soc Lond B Biol Sci Date: 2009-07-27 Impact factor: 6.237
Authors: Jörg Oehlmann; Ulrike Schulte-Oehlmann; Werner Kloas; Oana Jagnytsch; Ilka Lutz; Kresten O Kusk; Leah Wollenberger; Eduarda M Santos; Gregory C Paull; Katrien J W Van Look; Charles R Tyler Journal: Philos Trans R Soc Lond B Biol Sci Date: 2009-07-27 Impact factor: 6.237
Authors: Sarah Zulkifli; Amirah Abdul Rahman; Siti Hamimah Sheikh Abdul Kadir; Noor Shafina Mohd Nor Journal: Eur J Pediatr Date: 2021-04-24 Impact factor: 3.183