Literature DB >> 22828715

Serum microRNA biomarkers for drug-induced liver injury.

P J Starkey Lewis1, M Merz, P Couttet, O Grenet, J Dear, D J Antoine, C Goldring, B K Park, J G Moggs.   

Abstract

New biomarkers of drug-induced liver injury (DILI) are required in the clinic and in preclinical pharmaceutical evaluation. Liver-enriched microRNAs are promising serum biomarkers of acetaminophen-induced acute liver injury in mice. The utility of circulating microRNAs as biomarkers of human acute DILI is discussed in the context of correlation with existing biomarkers of liver injury and patient outcomes in acetaminophen toxicity, mechanisms of cellular microRNA release, and their potential advantages over current clinical biomarkers of DILI.

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Year:  2012        PMID： 22828715     DOI： 10.1038/clpt.2012.101

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  16 in total

1.  Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells.

Authors:  Li Chen; Alyssa Charrier; Yu Zhou; Ruju Chen; Bo Yu; Kitty Agarwal; Hidekazu Tsukamoto; L James Lee; Michael E Paulaitis; David R Brigstock
Journal:  Hepatology       Date:  2014-01-27       Impact factor: 17.425

Review 2.  [Diagnosis and therapies for acute liver failure: scientific developments].

Authors:  M Ott; T Cantz; A Schneider; M P Manns
Journal:  Internist (Berl)       Date:  2014-11       Impact factor: 0.743

3.  Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains.

Authors:  Isabelle R Miousse; Charles M Skinner; Haixia Lin; Laura E Ewing; Stanley D Kosanke; D Keith Williams; Bharathi Avula; Ikhlas A Khan; Mahmoud A ElSohly; Bill J Gurley; Igor Koturbash
Journal:  Food Chem Toxicol       Date:  2017-08-24       Impact factor: 6.023

Review 4.  Differential expression and functions of microRNAs in liver transplantation and potential use as non-invasive biomarkers.

Authors:  Liang Wei; Xue Gong; Olivia M Martinez; Sheri M Krams
Journal:  Transpl Immunol       Date:  2013-08-31       Impact factor: 1.708

5.  Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children.

Authors:  Xi Yang; William F Salminen; Qiang Shi; James Greenhaw; Pritmohinder S Gill; Sudeepa Bhattacharyya; Richard D Beger; Donna L Mendrick; William B Mattes; Laura P James
Journal:  Toxicol Appl Pharmacol       Date:  2015-02-21       Impact factor: 4.219

6.  Recent Advances in Understanding of NASH: MicroRNAs as Both Biochemical Markers and Players.

Authors:  Robert Vincent; Arun Sanyal
Journal:  Curr Pathobiol Rep       Date:  2014-09-01

7.  Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.

Authors:  John D Clarke; Tatiana Sharapova; April D Lake; Eric Blomme; Jonathan Maher; Nathan J Cherrington
Journal:  J Appl Toxicol       Date:  2013-11-12       Impact factor: 3.446

8.  Different normalization strategies might cause inconsistent variation in circulating microRNAs in patients with hepatocellular carcinoma.

Authors:  Gusheng Tang; Xiaojun Shen; Kaiyang Lv; Yu Wu; Jianwei Bi; Qian Shen
Journal:  Med Sci Monit       Date:  2015-02-26

Review 9.  Translational biomarkers of acetaminophen-induced acute liver injury.

Authors:  Richard D Beger; Sudeepa Bhattacharyya; Xi Yang; Pritmohinder S Gill; Laura K Schnackenberg; Jinchun Sun; Laura P James
Journal:  Arch Toxicol       Date:  2015-05-17       Impact factor: 5.153

10.  Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity.

Authors:  Adriaan D B Vliegenthart; Philip Starkey Lewis; Carl S Tucker; Jorge Del Pozo; Sebastein Rider; Daniel J Antoine; Valérie Dubost; Magdalena Westphal; Pierre Moulin; Matthew A Bailey; Jonathan G Moggs; Chris E Goldring; B Kevin Park; James W Dear
Journal:  Zebrafish       Date:  2014-03-13       Impact factor: 1.985
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