| Literature DB >> 22825547 |
Kiyoshi Migita1, Taiichiro Miyashita, Toma Mijin, Sohko Sakito, Hirokazu Kurohama, Masahiro Ito, Keisuke Toda, Keisuke Tsustumi, Hiroshi Baba, Yasumori Izumi, Atsushi Kawakami, Daisuke Niino, Kouichi Ohshima.
Abstract
Patients with rheumatoid arthritis (RA), especially those treated with methotrexate (MTX), might have an increased risk of lymphoproliferative disorders that are associated with Epstein-Barr virus (EBV). We describe a case of EBV-associated central nervous system (CNS) lymphoma (diffuse large B-cell lymphoma) in a patient with RA on a short course of MTX treatment. The neoplastic cells express the B-cell surface markers (CD20, Pax-5 and CD30), and EBV-encoded RNA was demonstrated by in situ hybridization. The patient's lymphoma did not recur for the 8-year follow-up period after the tumor resection and cessation of MTX. MTX may promote EBV-positive CNS lymphoma in RA patient due to its immunosuppressive properties as well as reactivating latent EBV infection.Entities:
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Year: 2012 PMID： 22825547 DOI： 10.1007/s10165-012-0717-7
Source DB: PubMed Journal: Mod Rheumatol ISSN： 1439-7595 Impact factor: 3.023