Literature DB >> 2282491

Effects of dietary zinc status on seizure susceptibility and hippocampal zinc content in the El (epilepsy) mouse.

M Fukahori1, M Itoh.   

Abstract

The effects of dietary zinc status on the development of convulsive seizures, and zinc concentrations in discrete hippocampal areas and other parts of the limbic system were studied in the El mouse model receiving zinc-adequate, zinc-deficient or zinc-loaded diets. Seizure susceptibility of the El mouse was increased by zinc deficiency, and decreased by zinc loading, while an adequate diet had no effect. Zinc loading was accompanied by a marked increase in hippocampal zinc content in the El mouse. Conversely, hippocampal zinc content declined in the El mouse fed a zinc-deficient diet. These results suggest that zinc may have a preventive effect on the development of seizures in the El mouse, and hippocampal zinc may play an important role in the pathophysiology of convulsive seizures of epilepsy.

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Year:  1990        PMID： 2282491     DOI： 10.1016/0006-8993(90)90806-m

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  24 in total

Review 1.  The neurophysiology and pathology of brain zinc.

Authors:  Stefano L Sensi; Pierre Paoletti; Jae-Young Koh; Elias Aizenman; Ashley I Bush; Michal Hershfinkel
Journal:  J Neurosci       Date:  2011-11-09       Impact factor: 6.167

2.  Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission.

Authors:  Einav Cohen-Kfir; William Lee; Sepehr Eskandari; Nathan Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-13       Impact factor: 11.205

3.  Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel.

Authors:  T R Cummins; J R Howe; S G Waxman
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

4.  SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro.

Authors:  R A Saadi; K He; K A Hartnett; K Kandler; M Hershfinkel; E Aizenman
Journal:  Neuroscience       Date:  2012-03-07       Impact factor: 3.590

5.  Association of serum trace elements and minerals with genetic generalized epilepsy and idiopathic intractable epilepsy.

Authors:  D K V Prasad; Uzma Shaheen; U Satyanarayana; T Surya Prabha; A Jyothy; Anjana Munshi
Journal:  Neurochem Res       Date:  2014-09-26       Impact factor: 3.996

6.  Low extracellular zinc increases neuronal oxidant production through nadph oxidase and nitric oxide synthase activation.

Authors:  Lucila Aimo; Gary N Cherr; Patricia I Oteiza
Journal:  Free Radic Biol Med       Date:  2010-03-06       Impact factor: 7.376

7.  Brain-Delivery of Zinc-Ions as Potential Treatment for Neurological Diseases: Mini Review.

Authors:  Andreas M Grabrucker; Magali Rowan; Craig C Garner
Journal:  Drug Deliv Lett       Date:  2011-09

8.  New seizure frequency QTL and the complex genetics of epilepsy in EL mice.

Authors:  W N Frankel; A Valenzuela; C M Lutz; E W Johnson; W F Dietrich; J M Coffin
Journal:  Mamm Genome       Date:  1995-12       Impact factor: 2.957

Review 9.  Synaptic Zn2+ and febrile seizure susceptibility.

Authors:  Christopher A Reid; Michael S Hildebrand; Saul A Mullen; Joanne M Hildebrand; Samuel F Berkovic; Steven Petrou
Journal:  Br J Pharmacol       Date:  2016-11-28       Impact factor: 8.739

10.  Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus.

Authors:  Limor Besser; Ehud Chorin; Israel Sekler; William F Silverman; Stan Atkin; James T Russell; Michal Hershfinkel
Journal:  J Neurosci       Date:  2009-03-04       Impact factor: 6.167
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