Literature DB >> 2282460

Reversible and selective antagonism by suramin of ATP-activated inward current in PC12 phaeochromocytoma cells.

K Nakazawa1, K Fujimori, A Takanaka, K Inoue.   

Abstract

1. The effects of suramin on an adenosine 5'-triphosphate (ATP)-activated inward current were investigated in PC12 phaeochromocytoma cells with whole-cell voltage-clamp techniques. 2. Suramin (30 to 300 microM) inhibited the ATP-activated current in a dose-dependent manner. The inhibitory effects were reversible and competitive. 3. Suramin also suppressed the current activated by adenosine 5'-O-(3-thiotriphosphate) but did not affect the current activated by nicotine. Suramin did not affect the suppression of a K current induced by methacholine. 4. The results suggest that suramin antagonizes the ATP-receptor-operated membrane current reversibly and selectively.

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Year:  1990        PMID： 2282460      PMCID： PMC1917622          DOI： 10.1111/j.1476-5381.1990.tb12117.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

Review 1.  ATP-activated channels in excitable cells.

Authors:  B P Bean; D D Friel
Journal:  Ion Channels       Date:  1990

2.  A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle.

Authors:  C D Benham; R W Tsien
Journal:  Nature       Date:  1987 Jul 16-22       Impact factor: 49.962

3.  The inhibitory action of suramin on the P2-purinoceptor response in smooth muscle cells of guinea-pig taenia caeci.

Authors:  A den Hertog; A Nelemans; J Van den Akker
Journal:  Eur J Pharmacol       Date:  1989-08-03       Impact factor: 4.432

4.  Muscarinic stimulation of calcium influx and norepinephrine release in PC12 cells.

Authors:  K Inoue; J G Kenimer
Journal:  J Biol Chem       Date:  1988-06-15       Impact factor: 5.157

5.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

6.  Three types of acetylcholine-induced single channel currents in clonal rat pheochromocytoma cells.

Authors:  J Bormann; H Matthaei
Journal:  Neurosci Lett       Date:  1983-09-30       Impact factor: 3.046

7.  Extracellular adenosine 5'-triphosphate-evoked norepinephrine secretion not relating to voltage-gated Ca channels in pheochromocytoma PC12 cells.

Authors:  K Inoue; K Nakazawa; K Fujimori; A Takanaka
Journal:  Neurosci Lett       Date:  1989-12-04       Impact factor: 3.046

8.  Receptors for ATP in rat sensory neurones: the structure-function relationship for ligands.

Authors:  O A Krishtal; S M Marchenko; A G Obukhov; T M Volkova
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

9.  An ATP-sensitive conductance in single smooth muscle cells from the rat vas deferens.

Authors:  D D Friel
Journal:  J Physiol       Date:  1988-07       Impact factor: 5.182

10.  Existence of muscarinic suppression of a K current in PC-12 pheochromocytoma cells.

Authors:  K Nakazawa; K Fujimori; A Takanaka; K Inoue
Journal:  Am J Physiol       Date:  1989-11
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  20 in total

1.  Inhibition of adenylyl cyclase by neuronal P2Y receptors.

Authors:  Ursula Unterberger; Eugenia Moskvina; Thomas Scholze; Michael Freissmuth; Stefan Boehm
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

2.  ATP mediates excitatory synaptic transmission in mammalian neurones.

Authors:  E M Silinsky; V Gerzanich; S M Vanner
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

3.  The nucleotide receptors on mouse C2C12 myotubes.

Authors:  R H Henning; A Nelemans; J van den Akker; A den Hertog
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

4.  Effects of the P2-purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5'-diphosphate.

Authors:  S M Hourani; D A Hall; C J Nieman
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

5.  Quinine sensitive changes in cellular Na+ and K+ homeostasis of COS-7 cells caused by a lipophilic phenol red impurity.

Authors:  L Hopp; C H Bunker; B W Day
Journal:  In Vitro Cell Dev Biol Anim       Date:  1995-05       Impact factor: 2.416

6.  Action of purine and pyrimidine nucleotides on the rat superior cervical ganglion.

Authors:  G P Connolly; P J Harrison; T W Stone
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

7.  On the excitatory effects of ATP and its role as a neurotransmitter in coeliac neurons of the guinea-pig.

Authors:  E M Silinsky; V Gerzanich
Journal:  J Physiol       Date:  1993-05       Impact factor: 5.182

8.  The effects of ATP and alpha,beta-methylene-ATP on cytosolic Ca2+ level and force in rat isolated aorta.

Authors:  S Kitajima; H Ozaki; H Karaki
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

9.  Mannose-induced dysmorphogenesis of metanephric kidney. Role of proteoglycans and adenosine triphosphate.

Authors:  Z Z Liu; F A Carone; T M Dalecki; B Lelongt; E I Wallner; Y S Kanwar
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

10.  Calcium release from separate receptor-specific intracellular stores induced by histamine and ATP in a hamster cell line.

Authors:  A Den Hertog; B Hoiting; A Molleman; J Van den Akker; M Duin; A Nelemans
Journal:  J Physiol       Date:  1992-08       Impact factor: 5.182
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