Literature DB >> 2282455

Inhibitory actions of prostaglandin E1 on non-adrenergic non-cholinergic contraction in guinea-pig bronchi.

T Aikawa1, K Sekizawa, S Itabashi, H Sasaki, T Takishima.   

Abstract

We have investigated the effect of prostaglandin E1 (PGE1) on non-adrenergic, non-cholinergic (NANC) contraction in guinea-pig bronchial strips. PGE1 (10 nM to 10 microM) did not alter baseline tension but reduced NANC contractions induced by electrical field stimulation (EFS) in a concentration-dependent fashion (-log EC50 was 6.60 +/- 0.10 M and maximum inhibition was 88.7 +/- 2.9%). PGE1 (greater than 0.3 microM) also reduced the contraction induced by substance P (1 microM). Removal of epithelium did not alter the effects of PGE1 on NANC contraction. These results suggest that PGE1 exerts both pre- and post-junctional inhibitory actions on NANC contraction.

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Year:  1990        PMID： 2282455      PMCID： PMC1917629          DOI： 10.1111/j.1476-5381.1990.tb12080.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

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Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

2.  Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.

Authors:  J Orehek; J S Douglas; A Bouhuys
Journal:  J Pharmacol Exp Ther       Date:  1975-09       Impact factor: 4.030

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Authors:  P J Barnes
Journal:  Lancet       Date:  1986-02-01       Impact factor: 79.321

4.  A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig.

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Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

5.  Actions of indomethacin and prostaglandins on neuro-effector transmission in the dog trachea.

Authors:  Y Ito; K Tajima
Journal:  J Physiol       Date:  1981       Impact factor: 5.182

6.  Prostaglandin generation by human and guinea pig lung tissue: comparison of parenchymal and airway responses.

Authors:  L Steel; L Platshon; M Kaliner
Journal:  J Allergy Clin Immunol       Date:  1979-10       Impact factor: 10.793

7.  THE INHIBITORY ACTIONS OF PROSTAGLANDINS ON RESPIRATORY SMOOTH MUSCLE.

Authors:  I H MAIN
Journal:  Br J Pharmacol Chemother       Date:  1964-06

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Authors:  J M Lundberg; T Hökfelt; C R Martling; A Saria; C Cuello
Journal:  Cell Tissue Res       Date:  1984       Impact factor: 5.249
  8 in total
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Review 1.  Central regulation of the cough reflex: therapeutic implications.

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Journal:  Pulm Pharmacol Ther       Date:  2009-01-20       Impact factor: 3.410

2.  The role of cyclic AMP in non-adrenergic non-cholinergic contraction in guinea-pig bronchi.

Authors:  T Aikawa; K Sekizawa; M Morikawa; S Itabashi; H Sasaki; T Takishima
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

3.  Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus.

Authors:  D Spina; S Harrison; C P Page
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

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Journal:  Handb Exp Pharmacol       Date:  2009
  4 in total

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