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Literature DB >> 22824431

Regulation of cholesterol biosynthesis and cancer signaling.

Andrey Gorin¹, Linara Gabitova, Igor Astsaturov.

Abstract

Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.

Entities: CellLine Chemical Disease Gene Species

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Year: 2012 PMID： 22824431 PMCID： PMC3504641 DOI： 10.1016/j.coph.2012.06.011

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

50 in total

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Journal: Oncogene Date: 2006-08-14 Impact factor: 9.867

Review 2. Intracellular trafficking of raft/caveolae domains: insights from integrin signaling.

Authors: Asier Echarri; Olivia Muriel; Miguel A Del Pozo
Journal: Semin Cell Dev Biol Date: 2007-08-19 Impact factor: 7.727

Review 3. Signaling on the endocytic pathway.

Authors: Mark von Zastrow; Alexander Sorkin
Journal: Curr Opin Cell Biol Date: 2007-07-26 Impact factor: 8.382

4. Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance.

Authors: Arun Radhakrishnan; Joseph L Goldstein; Jeffrey G McDonald; Michael S Brown
Journal: Cell Metab Date: 2008-12 Impact factor: 27.287

Review 5. Increased lipogenesis in cancer cells: new players, novel targets.

Authors: Johannes V Swinnen; Koen Brusselmans; Guido Verhoeven
Journal: Curr Opin Clin Nutr Metab Care Date: 2006-07 Impact factor: 4.294

6. ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism.

Authors: Saara Laitinen; Markku Lehto; Sanna Lehtonen; Kati Hyvärinen; Sanna Heino; Eero Lehtonen; Christian Ehnholm; Elina Ikonen; Vesa M Olkkonen
Journal: J Lipid Res Date: 2002-02 Impact factor: 5.922

7. OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation.

Authors: Ping-Yuan Wang; Jian Weng; Richard G W Anderson
Journal: Science Date: 2005-03-04 Impact factor: 47.728

8. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.

Authors: Sara Sigismund; Elisabetta Argenzio; Daniela Tosoni; Elena Cavallaro; Simona Polo; Pier Paolo Di Fiore
Journal: Dev Cell Date: 2008-08 Impact factor: 12.270

Review 9. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.

Authors: Javier A Menendez; Ruth Lupu
Journal: Nat Rev Cancer Date: 2007-10 Impact factor: 60.716

Review 10. Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders.

Authors: Lucien Corbeel; Kathleen Freson
Journal: Eur J Pediatr Date: 2008-05-08 Impact factor: 3.183

39 in total

1. Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells.

Authors: Jahnabi Roy; Payam Dibaeinia; Timothy M Fan; Saurabh Sinha; Aditi Das
Journal: J Lipid Res Date: 2018-11-30 Impact factor: 5.922

Review 2. Synthetic high-density lipoprotein-like nanoparticles as cancer therapy.

Authors: Kaylin M McMahon; Linda Foit; Nicholas L Angeloni; Francis J Giles; Leo I Gordon; C Shad Thaxton
Journal: Cancer Treat Res Date: 2015

3. 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.

Authors: Dylan T Jones; Alessandro Valli; Syed Haider; Qifeng Zhang; Elizabeth A Smethurst; Zachary T Schug; Barrie Peck; Eric O Aboagye; Susan E Critchlow; Almut Schulze; Eyal Gottlieb; Michael J O Wakelam; Adrian L Harris
Journal: Mol Cancer Ther Date: 2018-11-26 Impact factor: 6.261

Review 4. Effect of Membrane Composition on Receptor Association: Implications of Cancer Lipidomics on ErbB Receptors.

Authors: Aiswarya B Pawar; Durba Sengupta
Journal: J Membr Biol Date: 2018-01-19 Impact factor: 1.843

Review 5. Synthetic high-density lipoprotein-like nanoparticles for cancer therapy.

Authors: Linda Foit; Francis J Giles; Leo I Gordon; Colby Shad Thaxton
Journal: Expert Rev Anticancer Ther Date: 2014-12-09 Impact factor: 4.512

Review 6. Lipoproteins and lipoprotein mimetics for imaging and drug delivery.

Authors: C Shad Thaxton; Jonathan S Rink; Pratap C Naha; David P Cormode
Journal: Adv Drug Deliv Rev Date: 2016-04-29 Impact factor: 15.470

Review 7. Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy.

Authors: Isabella Giacomini; Federico Gianfanti; Maria Andrea Desbats; Genny Orso; Massimiliano Berretta; Tommaso Prayer-Galetti; Eugenio Ragazzi; Veronica Cocetta
Journal: Front Oncol Date: 2021-05-24 Impact factor: 6.244

8. Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

Authors: John P Thomson; Raffaele Ottaviano; Elif B Unterberger; Harri Lempiäinen; Arne Muller; Remi Terranova; Robert S Illingworth; Shaun Webb; Alastair R W Kerr; Marcus J Lyall; Amanda J Drake; C Roland Wolf; Jonathan G Moggs; Michael Schwarz; Richard R Meehan
Journal: Cancer Res Date: 2016-04-06 Impact factor: 12.701

9. Evaluation of Drug-Drug Interactions in EGFR-Mutated Non-Small-Cell Lung Cancer Patients during Treatment with Tyrosine-Kinase Inhibitors.

Authors: Mario Occhipinti; Marta Brambilla; Giulia Galli; Sara Manglaviti; Maristella Giammaruco; Arsela Prelaj; Roberto Ferrara; Alessandro De Toma; Claudia Proto; Teresa Beninato; Emma Zattarin; Giuseppe Lo Russo; Alain Jonathan Gelibter; Maurizio Simmaco; Robert Preissner; Marina Chiara Garassino; Filippo De Braud; Paolo Marchetti
Journal: J Pers Med Date: 2021-05-18

Review 10. The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics.

Authors: Pedro M R Cruz; Huanbiao Mo; Walter J McConathy; Nirupama Sabnis; Andras G Lacko
Journal: Front Pharmacol Date: 2013-09-25 Impact factor: 5.810