Literature DB >> 22824

Regulation of nerve growth factor content in C6 glioma cells by beta-adrenergic receptor stimulation.

J P Schwartz, E Costa.   

Abstract

The C6 glioma cell line contains nerve growth factor (NGF) which can be released into the medium. Treatment of the cells with beta-adrenoceptor agonists resulted in increased content of NGF in both the cells and the medium within a few hours, whereas alpha-adrenoceptor agonists were ineffective. The response was blocked by beta- but not alpha-adrenoceptor antagonists. The increase of the NGF content of glioma cells appeared to be mediated by an elevation of cyclic AMP or GMP. The addition to the cell cultures of other putative neurotransmitters failed to change the content of either NGF or cyclic AMP. These results are discussed with respect to a model for adrenergic neuron-glial interactions.

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Year:  1977        PMID： 22824     DOI： 10.1007/BF00505042

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  24 in total

1.  Increase in nerve growth factor content of C6 glioma cells by the activation of a beta-adrenergic receptor.

Authors:  J P Schwartz; D M Chuang; E Costa
Journal:  Brain Res       Date:  1977-12-02       Impact factor: 3.252

2.  Adenosine 3',5'-monophosphate in glial tumor cells. Alterations by 5-bromodeoxyuridine.

Authors:  J P Schwartz; N R Morris; B M Breckenridge
Journal:  J Biol Chem       Date:  1973-04-25       Impact factor: 5.157

3.  Studies on the mechanism of action of nerve growth factor.

Authors:  D B Hier; B G Arnason; M Young
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

4.  Mediation by cyclic AMP of hormone-stimulated glycogenolysis in cultured rat astrocytoma cells.

Authors:  L A Opler; M H Makman
Journal:  Biochem Biophys Res Commun       Date:  1972-02-16       Impact factor: 3.575

5.  Properties of the specific binding of 125I-nerve growth factor to responsive peripheral neurons.

Authors:  W A Frazier; L F Boyd; R A Bradshaw
Journal:  J Biol Chem       Date:  1974-09-10       Impact factor: 5.157

6.  Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons.

Authors:  A G Gilman; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1971-09       Impact factor: 11.205

7.  An improved method for isolation of H-2 and Ia alloantigens with immunoprecipitation induced by protein A-bearing staphylococci.

Authors:  S E Cullen; B D Schwartz
Journal:  J Immunol       Date:  1976-07       Impact factor: 5.422

8.  Cyclic AMP-mediated induction of the cyclic AMP phosphodiesterase of C-6 glioma cells.

Authors:  J P Schwartz; J V Passonneau
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

9.  Catecholamine-mediated elevation of cyclic GMP in the rat C-6 glioma cell line.

Authors:  J P Schwartz
Journal:  J Cyclic Nucleotide Res       Date:  1976 Jul-AUG

10.  Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine.

Authors:  R B Clark; J P Perkins
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205
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  6 in total

1.  Follicle-stimulating hormone-dependent phosphorylation of vimentin in cultures of rat Sertoli cells.

Authors:  W A Spruill; A L Steiner; L L Tres; A L Kierszenbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

2.  Beta-adrenergic receptor regulation, through cyclic AMP, of nerve growth factor expression in rat cortical and cerebellar astrocytes.

Authors:  J P Schwartz; K Mishler
Journal:  Cell Mol Neurobiol       Date:  1990-09       Impact factor: 5.046

3.  Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein.

Authors:  I Mocchetti; M A De Bernardi; A M Szekely; H Alho; G Brooker; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

4.  beta-adrenergic receptor-induced activation of nerve growth factor gene transcription in rat cerebral cortex involves CCAAT/enhancer-binding protein delta.

Authors:  A M Colangelo; P F Johnson; I Mocchetti
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

5.  Altered nerve growth factor in fibroblasts from patients with familial dysautonomia.

Authors:  J P Schwartz; X O Breakefield
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

6.  Vimentin: a phosphoprotein under hormonal regulation.

Authors:  E T Browning; M M Sanders
Journal:  J Cell Biol       Date:  1981-09       Impact factor: 10.539
  6 in total

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