OBJECTIVE: With the introduction of glycated hemoglobin (A1c) as a method of screening for diabetes, it is essential to study how use of A1c would affect the prevalence of diabetes in different ethnic groups. We compared the prevalence of diabetes by fasting (FPG) and 2-h post-load (75-g) plasma glucose (2-h PG) and A1c criteria in an Asian Indian population. RESEARCH DESIGN AND METHODS: Subjects (n=2,188) without known diabetes were drawn from the Chennai Urban Rural Epidemiological Study, a population-based study in Chennai, South India. FPG, 2-h PG, and A1c estimations were carried out. Prevalence rates of diabetes were compared using as cut points FPG ≥7 mmol/L (126 mg/dL), 2-hr PG ≥11.1 mmol/L (200 mg/dL), or A1c ≥6.5% criteria. RESULTS: Prevalence of diabetes was 6.1% (n=134) using the FPG criterion, 10.1% (n=221) by the 2-h PG criterion, and 12.8% (n=281) by the A1c criterion. Thus the prevalence of diabetes by the A1c criterion was 110% and 27% higher than the FPG and 2-hr PG criteria, respectively. Only 121 of these subjects were identified by all three criteria. Subjects diagnosed by the A1c criteria had the lowest FPG, 2-h PG, A1c, and serum triglyceride levels. CONCLUSIONS: In Asian Indians, use of A1c criteria would result in markedly higher prevalence rates of diabetes. It also identifies a different set of individuals with milder glucose intolerance and lower serum triglyceride levels.
OBJECTIVE: With the introduction of glycated hemoglobin (A1c) as a method of screening for diabetes, it is essential to study how use of A1c would affect the prevalence of diabetes in different ethnic groups. We compared the prevalence of diabetes by fasting (FPG) and 2-h post-load (75-g) plasma glucose (2-h PG) and A1c criteria in an Asian Indian population. RESEARCH DESIGN AND METHODS: Subjects (n=2,188) without known diabetes were drawn from the Chennai Urban Rural Epidemiological Study, a population-based study in Chennai, South India. FPG, 2-h PG, and A1c estimations were carried out. Prevalence rates of diabetes were compared using as cut points FPG ≥7 mmol/L (126 mg/dL), 2-hr PG ≥11.1 mmol/L (200 mg/dL), or A1c ≥6.5% criteria. RESULTS: Prevalence of diabetes was 6.1% (n=134) using the FPG criterion, 10.1% (n=221) by the 2-h PG criterion, and 12.8% (n=281) by the A1c criterion. Thus the prevalence of diabetes by the A1c criterion was 110% and 27% higher than the FPG and 2-hr PG criteria, respectively. Only 121 of these subjects were identified by all three criteria. Subjects diagnosed by the A1c criteria had the lowest FPG, 2-h PG, A1c, and serum triglyceride levels. CONCLUSIONS: In Asian Indians, use of A1c criteria would result in markedly higher prevalence rates of diabetes. It also identifies a different set of individuals with milder glucose intolerance and lower serum triglyceride levels.
Authors: U P Gujral; D Prabhakaran; R Pradeepa; N R Kandula; D Kondal; M Deepa; N A Zakai; R M Anjana; G Rautela; V Mohan; K M V Narayan; N Tandon; A M Kanaya Journal: Diabetes Res Clin Pract Date: 2019-05-28 Impact factor: 5.602
Authors: Mohan Deepa; Mundu Grace; Bhaskarapillai Binukumar; Rajendra Pradeepa; Shivashankar Roopa; Hassan M Khan; Zafar Fatmi; Muhammad M Kadir; Imran Naeem; Vamadevan S Ajay; Ranjit Mohan Anjana; Mohammed K Ali; Dorairaj Prabhakaran; Nikhil Tandon; Viswanathan Mohan; K M Venkat Narayan Journal: Diabetes Res Clin Pract Date: 2015-09-25 Impact factor: 5.602
Authors: Arti D Shah; Eric Vittinghoff; Namratha R Kandula; Shweta Srivastava; Alka M Kanaya Journal: Ann Epidemiol Date: 2014-10-22 Impact factor: 3.797
Authors: Axel C Carlsson; Per Wändell; Urban Ösby; Ramin Zarrinkoub; Björn Wettermark; Gunnar Ljunggren Journal: BMC Public Health Date: 2013-07-18 Impact factor: 3.295