Literature DB >> 22822525

Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim. & Udagawa.

Periyasamy Giridharan1, Shilpa Amit Verekar, Amit Khanna, P D Mishra, Sunil Kumar Deshmukh.   

Abstract

Biodiversity provides critical support for drug discovery. A significant proportion of drugs are derived, directly or indirectly, from biological sources. Through high throughput screening (HTS) and bioassay-guided isolation, bioactive compound sclerotiorin has been isolated from an endophytic fungus Cephalotheca faveolata. Sclerotiorin was found to be potent anti-proliferative against different cancer cells. In this study sclerotiorin has been found to induce apoptosis in colon cancer (HCT-116) cells through the activation of BAX, and down-regulation of BCL-2, those further activated cleaved caspase-3 causing apoptosis of cancer cells.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22822525

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN： 0019-5189            Impact factor:   0.818


  8 in total

1.  Preparation, Structure, and Potent Antifouling Activity of Sclerotioramine Derivatives.

Authors:  Mei-Yan Wei; Cui-Fang Wang; Kai-Ling Wang; Pei-Yuan Qian; Chang-Yun Wang; Chang-Lun Shao
Journal:  Mar Biotechnol (NY)       Date:  2017-07-07       Impact factor: 3.619

2.  Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity.

Authors:  Fatima Zahra Kabbaj; Su Lu; My El Abbés Faouzi; Bouchra Meddah; Peter Proksch; Yahya Cherrah; Hans-Josef Altenbach; Amal H Aly; Ahmed Chadli; Abdessamad Debbab
Journal:  Bioorg Med Chem       Date:  2014-11-20       Impact factor: 3.641

3.  Antimicrobial activity and metabolite profiling of endophytic fungi in Digitaria bicornis (Lam) Roem. and Schult. and Paspalidium flavidum (Retz.) A. Camus.

Authors:  R Nischitha; M B Shivanna
Journal:  3 Biotech       Date:  2021-01-11       Impact factor: 2.406

4.  Antiproliferative activity of hamigerone and radicinol isolated from Bipolaris papendorfii.

Authors:  Periyasamy Giridharan; Shilpa A Verekar; Akash R Gohil; Prabhu Dutt Mishra; Amit Khanna; Sunil Kumar Deshmukh
Journal:  Biomed Res Int       Date:  2014-08-12       Impact factor: 3.411

5.  First report on a novel Nigrospora sphaerica isolated from Catharanthus roseus plant with anticarcinogenic properties.

Authors:  Farah Wahida Ayob; Khanom Simarani; Nurhayati Zainal Abidin; Jamaludin Mohamad
Journal:  Microb Biotechnol       Date:  2017-06-14       Impact factor: 5.813

6.  Antimicrobial Metabolites Produced by Penicillium mallochii CCH01 Isolated From the Gut of Ectropis oblique, Cultivated in the Presence of a Histone Deacetylase Inhibitor.

Authors:  Shuxiang Zhang; Han Fang; Caiping Yin; Chaoling Wei; Jingwei Hu; Yinglao Zhang
Journal:  Front Microbiol       Date:  2019-10-02       Impact factor: 5.640

7.  Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction.

Authors:  Lan Lan; Jiajun Liu; Minli Xing; Amber R Smith; Jinan Wang; Xiaoqing Wu; Carl Appelman; Ke Li; Anuradha Roy; Ragul Gowthaman; John Karanicolas; Amber D Somoza; Clay C C Wang; Yinglong Miao; Roberto De Guzman; Berl R Oakley; Kristi L Neufeld; Liang Xu
Journal:  Cancers (Basel)       Date:  2020-08-08       Impact factor: 6.639

Review 8.  Fungal Pigments and Their Roles Associated with Human Health.

Authors:  Lan Lin; Jianping Xu
Journal:  J Fungi (Basel)       Date:  2020-11-12
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.