Literature DB >> 22822264

Target Detection via Network Filtering.

Shu Yang1, Eric D Kolaczyk.   

Abstract

A method of 'network filtering' has been proposed recently to detect the effects of certain external perturbations on the interacting members in a network. However, with large networks, the goal of detection seems a priori difficult to achieve, especially since the number of observations available often is much smaller than the number of variables describing the effects of the underlying network. Under the assumption that the network possesses a certain sparsity property, we provide a formal characterization of the accuracy with which the external effects can be detected, using a network filtering system that combines Lasso regression in a sparse simultaneous equation model with simple residual analysis. We explore the implications of the technical conditions underlying our characterization, in the context of various network topologies, and we illustrate our method using simulated data.

Entities:  

Year:  2010        PMID: 22822264      PMCID: PMC3400183          DOI: 10.1109/TIT.2010.2043770

Source DB:  PubMed          Journal:  IEEE Trans Inf Theory        ISSN: 0018-9448            Impact factor:   2.501


  3 in total

1.  Emergence of scaling in random networks

Authors: 
Journal:  Science       Date:  1999-10-15       Impact factor: 47.728

2.  Efficient generation of large random networks.

Authors:  Vladimir Batagelj; Ulrik Brandes
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2005-03-11

3.  Predicting gene targets of perturbations via network-based filtering of mRNA expression compendia.

Authors:  Elissa J Cosgrove; Yingchun Zhou; Timothy S Gardner; Eric D Kolaczyk
Journal:  Bioinformatics       Date:  2008-09-08       Impact factor: 6.937

  3 in total
  1 in total

1.  Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets.

Authors:  Lisa M Christadore; Lisa Pham; Eric D Kolaczyk; Scott E Schaus
Journal:  BMC Syst Biol       Date:  2014-01-20
  1 in total

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