BACKGROUND: Alterations in heart rate variability (HRV) are a potential link between exposure to traffic-related air pollution and cardiovascular mortality. OBJECTIVES: We investigated whether long-term exposure to traffic-related PM(10) (TPM(10)) is associated with HRV in older subjects and/or in participants taking specific cardiovascular treatment or with self-reported heart disease. METHODS: We included 1607 subjects from the general population aged 50 to 72 years. These participants from the SAPALDIA cohort underwent ambulatory 24-hr electrocardiogram monitoring. Associations of average annual exposure to TPM(10) over 10 years with HRV parameters from time and frequency domains were estimated using multivariable mixed linear models. Effect estimates are expressed as percent changes in geometric means. RESULTS: HRV was only associated with TPM(10) in participants under ACE inhibitor therapy (N=94). A 1 μg/m(3) increment, approximately equivalent to an interquartile range, in 10 year average TPM(10) was associated with decrements of 14.5% (95% confidence interval (CI), -25.9 to -1.3) in high frequency (HF) power, of 4.5% (-8.2 to -0.5) in the standard deviation of all normal-to-normal RR intervals (SDNN), of 10.6% (-18.5 to -1.9) in total power (TP) and an increase of 9.2% (0.8 to 20.2) in the LF/HF power ratio. CONCLUSIONS: In the absence of an overall effect our results suggest that alterations in HRV, a measure of autonomic control of the cardiac rhythm, may not be a central mechanism by which long-term exposure to TPM(10) increases cardiovascular mortality. Novel evidence on an effect in persons under ACE inhibitor treatment needs to be confirmed in future studies.
BACKGROUND: Alterations in heart rate variability (HRV) are a potential link between exposure to traffic-related air pollution and cardiovascular mortality. OBJECTIVES: We investigated whether long-term exposure to traffic-related PM(10) (TPM(10)) is associated with HRV in older subjects and/or in participants taking specific cardiovascular treatment or with self-reported heart disease. METHODS: We included 1607 subjects from the general population aged 50 to 72 years. These participants from the SAPALDIA cohort underwent ambulatory 24-hr electrocardiogram monitoring. Associations of average annual exposure to TPM(10) over 10 years with HRV parameters from time and frequency domains were estimated using multivariable mixed linear models. Effect estimates are expressed as percent changes in geometric means. RESULTS: HRV was only associated with TPM(10) in participants under ACE inhibitor therapy (N=94). A 1 μg/m(3) increment, approximately equivalent to an interquartile range, in 10 year average TPM(10) was associated with decrements of 14.5% (95% confidence interval (CI), -25.9 to -1.3) in high frequency (HF) power, of 4.5% (-8.2 to -0.5) in the standard deviation of all normal-to-normal RR intervals (SDNN), of 10.6% (-18.5 to -1.9) in total power (TP) and an increase of 9.2% (0.8 to 20.2) in the LF/HF power ratio. CONCLUSIONS: In the absence of an overall effect our results suggest that alterations in HRV, a measure of autonomic control of the cardiac rhythm, may not be a central mechanism by which long-term exposure to TPM(10) increases cardiovascular mortality. Novel evidence on an effect in persons under ACE inhibitor treatment needs to be confirmed in future studies.
Authors: Virginia L Bass; Mette C Schladweiler; Abraham Nyska; Ronald F Thomas; Desinia B Miller; Todd Krantz; Charly King; M Ian Gilmour; Allen D Ledbetter; Judy E Richards; Urmila P Kodavanti Journal: Inhal Toxicol Date: 2015 Impact factor: 2.724
Authors: George D Thurston; Howard Kipen; Isabella Annesi-Maesano; John Balmes; Robert D Brook; Kevin Cromar; Sara De Matteis; Francesco Forastiere; Bertil Forsberg; Mark W Frampton; Jonathan Grigg; Dick Heederik; Frank J Kelly; Nino Kuenzli; Robert Laumbach; Annette Peters; Sanjay T Rajagopalan; David Rich; Beate Ritz; Jonathan M Samet; Thomas Sandstrom; Torben Sigsgaard; Jordi Sunyer; Bert Brunekreef Journal: Eur Respir J Date: 2017-01-11 Impact factor: 16.671
Authors: Richa Adhikari; Jennifer D'Souza; Elsayed Z Soliman; Gregory L Burke; Martha L Daviglus; David R Jacobs; Sung Kyun Park; Lianne Sheppard; Peter S Thorne; Joel D Kaufman; Timothy V Larson; Sara Dubowsky Adar Journal: Epidemiology Date: 2016-05 Impact factor: 4.822
Authors: Rahul Gondalia; Antoine Baldassari; Katelyn M Holliday; Anne E Justice; James D Stewart; Duanping Liao; Jeff D Yanosky; Stephanie M Engel; David Sheps; Kristina M Jordahl; Parveen Bhatti; Steve Horvath; Themistocles L Assimes; Ellen W Demerath; Weihua Guan; Myriam Fornage; Jan Bressler; Kari E North; Karen N Conneely; Yun Li; Lifang Hou; Andrea A Baccarelli; Eric A Whitsel Journal: Environ Res Date: 2021-04-22 Impact factor: 8.431
Authors: Scott M Bartell; John Longhurst; Thomas Tjoa; Constantinos Sioutas; Ralph J Delfino Journal: Environ Health Perspect Date: 2013-07-09 Impact factor: 9.031