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Literature DB >> 22820117

Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?

Aaron K Holley¹, Sanjit Kumar Dhar, Daret K St Clair.

Abstract

Reactive oxygen species (ROS), while vital for normal cellular function, can have harmful effects on cells, leading to the development of diseases such as cancer. The Warburg effect, the shift from oxidative phosphorylation to glycolysis, even in the presence of adequate oxygen, is an important metabolic change that confers many growth and survival advantages to cancer cells. Reactive oxygen species are important regulators of the Warburg effect. The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. MnSOD is important in cancer development and progression. However, the significance of MnSOD in the regulation of the Warburg effect is just now being revealed, and it may significantly impact the treatment of cancer in the future.

Entities: Chemical Disease Gene

Mesh：

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Year: 2012 PMID： 22820117 PMCID： PMC4604438 DOI： 10.1016/j.mito.2012.07.104

Source DB: PubMed Journal: Mitochondrion ISSN： 1567-7249 Impact factor: 4.160

344 in total

Review 1. Role of superoxide dismutase in cancer: a review.

Authors: L W Oberley; G R Buettner
Journal: Cancer Res Date: 1979-04 Impact factor: 12.701

2. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice.

Authors: H C Yen; T D Oberley; S Vichitbandha; Y S Ho; D K St Clair
Journal: J Clin Invest Date: 1996-09-01 Impact factor: 14.808

3. Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis.

Authors: J E Kokoszka; P Coskun; L A Esposito; D C Wallace
Journal: Proc Natl Acad Sci U S A Date: 2001-02-13 Impact factor: 11.205

Review 4. MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice.

Authors: Abdellah Mansouri; Arige Tarhuni; Isabelle Larosche; Florence Reyl-Desmars; Christine Demeilliers; Françoise Degoul; Pierre Nahon; Angela Sutton; Richard Moreau; Bernard Fromenty; Dominique Pessayre
Journal: Dig Dis Date: 2011-04-27 Impact factor: 2.404

5. Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.

Authors: Joon Hyuk Choi; Tae Nyeun Kim; Seongyong Kim; Suk-Hwan Baek; Jung Hye Kim; Seung Rock Lee; Jae-Ryong Kim
Journal: Anticancer Res Date: 2002 Nov-Dec Impact factor: 2.480

6. The reaction of no with superoxide.

Authors: R E Huie; S Padmaja
Journal: Free Radic Res Commun Date: 1993

7. Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria.

Authors: L Zhang; L Yu; C A Yu
Journal: J Biol Chem Date: 1998-12-18 Impact factor: 5.157

Review 8. Chemotherapy and cognitive deficits: mechanisms, findings, and potential interventions.

Authors: Christian J Nelson; Nina Nandy; Andrew J Roth
Journal: Palliat Support Care Date: 2007-09

9. Expression of manganese superoxide dismutase reduces tumor control radiation dose: gene-radiotherapy.

Authors: M Urano; M Kuroda; R Reynolds; T D Oberley; D K St Clair
Journal: Cancer Res Date: 1995-06-15 Impact factor: 12.701

10. Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma.

Authors: E Tsanou; E Ioachim; E Briasoulis; K Damala; A Charchanti; V Karavasilis; N Pavlidis; N J Agnantis
Journal: Histol Histopathol Date: 2004-07 Impact factor: 2.303

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Authors: Xiaofei Chen; Jade Mims; Xiumei Huang; Naveen Singh; Edward Motea; Sarah M Planchon; Muhammad Beg; Allen W Tsang; Mercedes Porosnicu; Melissa L Kemp; David A Boothman; Cristina M Furdui
Journal: Antioxid Redox Signal Date: 2017-12-20 Impact factor: 8.401

2. Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts.

Authors: Pawan Noel; Ruben Muñoz; George W Rogers; Andrew Neilson; Daniel D Von Hoff; Haiyong Han
Journal: J Vis Exp Date: 2017-08-23 Impact factor: 1.355

Review 3. Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer.

Authors: Luksana Chaiswing; William H St Clair; Daret K St Clair
Journal: Antioxid Redox Signal Date: 2018-02-21 Impact factor: 8.401

4. UCP2 promotes proliferation and chemoresistance through regulating the NF-κB/β-catenin axis and mitochondrial ROS in gallbladder cancer.

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