Literature DB >> 22820036

Autotaxin in liver fibrosis.

Hitoshi Ikeda1, Yutaka Yatomi.   

Abstract

Autotaxin (ATX) hydrolyzes lysophosphatidylcholine to produce lysophosphatidic acid (LPA), a multi-functional bioactive lipid mediator. ATX is a major determinant of LPA levels in the blood, and the pathophysiological functions of ATX are thought to be largely attributed to its ability to produce LPA. Liver fibrosis is one of the rare disorders exhibiting the increased ATX and LPA levels in the blood. This review summarizes the recent findings on the relation between ATX or LPA and liver fibrosis, the usefulness of serum ATX levels to predict the stages of liver fibrosis, and speculated roles of increased serum ATX and plasma LPA levels in liver fibrosis.
Copyright © 2012 Elsevier B.V. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22820036     DOI： 10.1016/j.cca.2012.07.014

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN： 0009-8981            Impact factor:   3.786


  19 in total

Review 1.  Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.

Authors:  Andrew J Sawyer; Themis R Kyriakides
Journal:  Adv Drug Deliv Rev       Date:  2016-01-04       Impact factor: 15.470

2.  Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.

Authors:  James I Fells; Sue Chin Lee; Yuko Fujiwara; Derek D Norman; Keng Gat Lim; Ryoko Tsukahara; Jianxiong Liu; Renukadevi Patil; Duane D Miller; R Jason Kirby; Sandra Nelson; William Seibel; Ruben Papoian; Abby L Parrill; Daniel L Baker; Robert Bittman; Gabor Tigyi
Journal:  Mol Pharmacol       Date:  2013-06-21       Impact factor: 4.436

3.  Adipose tissue fibrosis.

Authors:  Christa Buechler; Sabrina Krautbauer; Kristina Eisinger
Journal:  World J Diabetes       Date:  2015-05-15

4.  During Hepatitis C Virus (HCV) Infection and HCV-HIV Coinfection, an Elevated Plasma Level of Autotaxin Is Associated With Lysophosphatidic Acid and Markers of Immune Activation That Normalize During Interferon-Free HCV Therapy.

Authors:  Lenche Kostadinova; Carey L Shive; Chelsey Judge; Elizabeth Zebrowski; Anita Compan; Kelsey Rife; Amy Hirsch; Yngve Falck-Ytter; Daniela M Schlatzer; Xiaolin Li; Mark R Chance; Benigno Rodriguez; Daniel L Popkin; Donald D Anthony
Journal:  J Infect Dis       Date:  2016-08-17       Impact factor: 5.226

5.  Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis.

Authors:  Andrew J Haak; Enis Kostallari; Delphine Sicard; Giovanni Ligresti; Kyoung Moo Choi; Nunzia Caporarello; Dakota L Jones; Qi Tan; Jeffrey Meridew; Ana M Diaz Espinosa; Aja Aravamudhan; Jessica L Maiers; Rodney D Britt; Anja C Roden; Christina M Pabelick; Y S Prakash; Seyed Mehdi Nouraie; Xiaoyun Li; Yingze Zhang; Daniel J Kass; David Lagares; Andrew M Tager; Xaralabos Varelas; Vijay H Shah; Daniel J Tschumperlin
Journal:  Sci Transl Med       Date:  2019-10-30       Impact factor: 17.956

6.  Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease.

Authors:  Takashi Hirata; Stanley V Smith; Teisuke Takahashi; Noriyuki Miyata; Richard J Roman
Journal:  J Pharmacol Exp Ther       Date:  2020-12-04       Impact factor: 4.030

7.  Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity.

Authors:  Vikrant P Rachakonda; Valerie L Reeves; Jules Aljammal; Rachel C Wills; Joy S Trybula; James P DeLany; Petra C Kienesberger; Erin E Kershaw
Journal:  Obesity (Silver Spring)       Date:  2015-04-10       Impact factor: 5.002

8.  Analysis of glycero-lysophospholipids in gastric cancerous ascites.

Authors:  Shigenobu Emoto; Makoto Kurano; Kuniyuki Kano; Keisuke Matsusaki; Hiroharu Yamashita; Masako Nishikawa; Koji Igarashi; Hitoshi Ikeda; Junken Aoki; Joji Kitayama; Yutaka Yatomi
Journal:  J Lipid Res       Date:  2017-01-31       Impact factor: 5.922

9.  Association between Promoter Hypomethylation and Overexpression of Autotaxin with Outcome Parameters in Biliary Atresia.

Authors:  Wanvisa Udomsinprasert; Nakarin Kitkumthorn; Apiwat Mutirangura; Voranush Chongsrisawat; Yong Poovorawan; Sittisak Honsawek
Journal:  PLoS One       Date:  2017-01-04       Impact factor: 3.240

10.  Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells.

Authors:  Valentina Zuckerman; Eugene Sokolov; Jacob H Swet; William A Ahrens; Victor Showlater; David A Iannitti; Iain H Mckillop
Journal:  Oncotarget       Date:  2016-01-19
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.