BACKGROUND: Pseudomonas aeruginosa sinusitis may be the focus for intermittent lung colonization in patients with cystic fibrosis (CF). The sinusitis may induce elevated IgA levels in nasal secretion and saliva against P. aeruginosa. METHODS: 120 CF patients chronically infected, intermittently colonized or without P. aeruginosa in the lungs participated in this cross-sectional study. IgA and IgG against P. aeruginosa sonicate and alginate were measured in nasal secretions, saliva, and in serum by ELISA. RESULTS: The intermittently colonized patients had significantly higher IgA levels in nasal secretions and saliva than those without P. aeruginosa in the lungs, indicating that P. aeruginosa sinusitis may precede intermittent colonization and chronic infection of the lungs. CONCLUSIONS: Specific IgA against P. aeruginosa in nasal secretions and saliva can contribute to differentiation between patients chronically infected, intermittently colonized, and without P. aeruginosa in the lungs. The diagnostic value of the IgA ELISA awaits a prospective study.
BACKGROUND:Pseudomonas aeruginosasinusitis may be the focus for intermittent lung colonization in patients with cystic fibrosis (CF). The sinusitis may induce elevated IgA levels in nasal secretion and saliva against P. aeruginosa. METHODS: 120 CFpatients chronically infected, intermittently colonized or without P. aeruginosa in the lungs participated in this cross-sectional study. IgA and IgG against P. aeruginosa sonicate and alginate were measured in nasal secretions, saliva, and in serum by ELISA. RESULTS: The intermittently colonized patients had significantly higher IgA levels in nasal secretions and saliva than those without P. aeruginosa in the lungs, indicating that P. aeruginosa sinusitis may precede intermittent colonization and chronic infection of the lungs. CONCLUSIONS: Specific IgA against P. aeruginosa in nasal secretions and saliva can contribute to differentiation between patients chronically infected, intermittently colonized, and without P. aeruginosa in the lungs. The diagnostic value of the IgA ELISA awaits a prospective study.
Authors: Renan Marrichi Mauch; Claudio Lucio Rossi; Marcos Tadeu Nolasco da Silva; Talita Bianchi Aiello; José Dirceu Ribeiro; Antônio Fernando Ribeiro; Niels Høiby; Carlos Emilio Levy Journal: Med Microbiol Immunol Date: 2019-01-31 Impact factor: 3.402
Authors: Jochen G Mainz; Andrea Gerber; Michael Lorenz; Ruth Michl; Julia Hentschel; Anika Nader; James F Beck; Mathias W Pletz; Andreas H Mueller Journal: Case Rep Infect Dis Date: 2015-03-18
Authors: Jada C Domingue; Julia L Drewes; Christian A Merlo; Franck Housseau; Cynthia L Sears Journal: Mucosal Immunol Date: 2020-02-28 Impact factor: 7.313
Authors: Jochen G Mainz; Katja Schädlich; Claudia Schien; Ruth Michl; Petra Schelhorn-Neise; Assen Koitschev; Christiane Koitschev; Peter M Keller; Joachim Riethmüller; Baerbel Wiedemann; James F Beck Journal: Drug Des Devel Ther Date: 2014-02-10 Impact factor: 4.162