OBJECTIVE: The aim of this retrospective study was to investigate the association between the pretreatment apparent diffusion coefficient (ADC) value and recurrence of bladder cancer after transurethral resection. METHODS: Patients with superficial bladder cancer were identified. Mean ADC values of the tumors were compared between patients with and without recurrence following trans-urethral resection. A receiver-operator characteristic curve was used for determining the optimal cutoff ADC value. Univariate and multivariate analyses were used to determine the effect of ADC values and other factors. RESULTS: With a mean follow-up period of 25 months, bladder cancer recurred in 14 of 44 patients (32%). The mean ADC value of tumors in patients with recurrence was lower than in those without recurrence (1.08 mm2/s vs. 1.28×10(-3) mm2/s; p=0.003). The optimal cutoff ADC value for predicting recurrence was determined to be 1.12×10(-3) mm2/s. A modest and significant negative correlation was observed between the ADC values and tumor size (r=-0.436, p=0.008). After adjustment for size and risk groups, an ADC value equal to or less than the optimal cutoff remained a significant predictor of recurrence (odds ratio 6.3, 95% CI 1.23-32.2, p=0.027). CONCLUSION: Pretreatment ADC values may be an independent predictor of bladder cancer recurrence.
OBJECTIVE: The aim of this retrospective study was to investigate the association between the pretreatment apparent diffusion coefficient (ADC) value and recurrence of bladder cancer after transurethral resection. METHODS:Patients with superficial bladder cancer were identified. Mean ADC values of the tumors were compared between patients with and without recurrence following trans-urethral resection. A receiver-operator characteristic curve was used for determining the optimal cutoff ADC value. Univariate and multivariate analyses were used to determine the effect of ADC values and other factors. RESULTS: With a mean follow-up period of 25 months, bladder cancer recurred in 14 of 44 patients (32%). The mean ADC value of tumors in patients with recurrence was lower than in those without recurrence (1.08 mm2/s vs. 1.28×10(-3) mm2/s; p=0.003). The optimal cutoff ADC value for predicting recurrence was determined to be 1.12×10(-3) mm2/s. A modest and significant negative correlation was observed between the ADC values and tumor size (r=-0.436, p=0.008). After adjustment for size and risk groups, an ADC value equal to or less than the optimal cutoff remained a significant predictor of recurrence (odds ratio 6.3, 95% CI 1.23-32.2, p=0.027). CONCLUSION: Pretreatment ADC values may be an independent predictor of bladder cancer recurrence.
Authors: Andrew B Rosenkrantz; Arjun V Balar; William C Huang; Kimberly Jackson; Kent P Friedman Journal: Clin Nucl Med Date: 2015-08 Impact factor: 7.794