Literature DB >> 22817742

SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer.

Elaine A Hong1, Hannah L Gautrey, David J Elliott, Alison J Tyson-Capper.   

Abstract

SAFB1 (scaffold attachment factor B1) and a second family member SAFB2, are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors has been proposed based on well-described roles in tran-scriptional repression. The present review summarizes the current knowledge of SAFB1 and SAFB2 proteins in transcriptional repression with relevance to cancer.

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Year:  2012        PMID： 22817742     DOI： 10.1042/BST20120030

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


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