OBJECTIVE: To study the contribution of lactate and procalcitonin (PCT) serum measurements for the diagnosis and the risk-stratification of patients with suspected infection presenting to the ED. METHODS: Single-center one year observational study on 462 consecutive patients. Multivariate analysis to assess variables associated with sepsis, severe sepsis, septic shock and severe outcome. RESULTS: Multivariate analysis (Odds ratio [95% CI]), showed that PCT was the best independent variable to identify sepsis (3.98 [2.60-6.10]), while lactate was the best to diagnose severe sepsis (10.88 [6.51-18.19]). Patients with both lactate above 2 mmol·L(-1) and PCT above 0.8 ng·mL(-1) had an enhanced risk of severe outcome. CONCLUSIONS: the dosages of lactate and PCT are complementary for the diagnosis and risk-stratification of patients evaluated in the ED for suspected infection.
OBJECTIVE: To study the contribution of lactate and procalcitonin (PCT) serum measurements for the diagnosis and the risk-stratification of patients with suspected infection presenting to the ED. METHODS: Single-center one year observational study on 462 consecutive patients. Multivariate analysis to assess variables associated with sepsis, severe sepsis, septic shock and severe outcome. RESULTS: Multivariate analysis (Odds ratio [95% CI]), showed that PCT was the best independent variable to identify sepsis (3.98 [2.60-6.10]), while lactate was the best to diagnose severe sepsis (10.88 [6.51-18.19]). Patients with both lactate above 2 mmol·L(-1) and PCT above 0.8 ng·mL(-1) had an enhanced risk of severe outcome. CONCLUSIONS: the dosages of lactate and PCT are complementary for the diagnosis and risk-stratification of patients evaluated in the ED for suspected infection.
Authors: Stephen P J Macdonald; Shelley F Stone; Claire L Neil; Pauline E van Eeden; Daniel M Fatovich; Glenn Arendts; Simon G A Brown Journal: PLoS One Date: 2014-10-24 Impact factor: 3.240
Authors: Daniel J Henning; Kimie Oedorf; Danielle E Day; Colby S Redfield; Colin J Huguenel; Jonathan C Roberts; Leon D Sanchez; Richard E Wolfe; Nathan I Shapiro Journal: West J Emerg Med Date: 2015-12-08
Authors: Noortje Zelis; Robin Hundscheid; Jacqueline Buijs; Peter W De Leeuw; Maarten Tm Raijmakers; Sander Mj van Kuijk; Patricia M Stassen Journal: BMJ Open Date: 2021-01-31 Impact factor: 2.692